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Multiphase Flows with
Droplets and Particles
Multiphase Flows with Droplets and Particles provides an organized, pedagogical
study of multiphase flows with particles and droplets. This revised edition presents
new information on particle interactions, particle collisions, thermophoresis and
Brownian movement, computational techniques and codes, and the treatment of
irregularly shaped particles. An entire chapter is devoted to the flow of nanoparticles
and applications of nanofluids.
FEATURES
• Discusses the modelling and analysis of nanoparticles.
• Covers all fundamental aspects of particle and droplet flows.
• Includes heat and mass transfer processes.
• Features new and updated sections throughout the text.
• Includes chapter exercises and a Solutions Manual for adopting instructors.
Designed to complement a graduate course in multiphase flows, the book can also
serve as a supplement in short courses for engineers or as a stand-alone reference for
engineers and scientists who work in this area.
Multiphase Flows with
Droplets and Particles
Third Edition
Efstathios E. Michaelides,
Martin Sommerfeld and
Berend van Wachem
v
vi Contents
LATIN SYMBOLS
a particle radius, radius of curvature [m]
A projected area [m 2], Hamaker constant [J]
Ai cross-sectional area at station i [m2]
Ac acceleration parameter [−]
Ar Archimedes number
B transfer number [−]
c speed of sound [m/s], particle circularity [−]
cd specific heat of dispersed phase [J/kg-K]
cp specific heat of continuous phase at constant pressure [J/kg-K]
C mass concentration [−]
CB coefficient for Basset force equation [−]
CD drag coefficient [−]
Cs thermal slip coefficient [−]
CS Smagorinsky coefficient [−]
CLR lift coefficient due to particle rotation [−]
Ct thermal exchange coefficient [−]
Cυm coefficient for virtual mass force equation [−]
Cμ coefficient for turbulence effective viscosity [−]
C ε1 coefficient for production of dissipation [−]
C ε2 coefficient for dissipation of dissipation [−]
C ε3 coefficient for particle production of dissipation [−]
df fringe spacing [m]
D Particle diameter [m]
DA area-equivalent sphere diameter [m]
DM median diameter [m]
DV volume-equivalent sphere diameter [m]
DT throat diameter [m]
D diffusivity [m2/s]
Dε diffusion of dissipation [kg/m · s3]
D average diameter [m]
D32 Sauter mean diameter [m]
e coefficient of restitution [−], charge on an electron [C]
E energy [J], Youngs modulus [Pa]
xiii
xiv Nomenclature
GREEK SYMBOLS
α volume fraction [−]
αc thermal diffusivity of continuous phase [m 2/s]
β thermal expansion coefficient [1/K]
βV parameter for momentum coupling [Ns/m4]
γ flow shear [s-1]; dissipation of granular temperature [kg/ms3]; ratio of
specific heats [−]
ε emissivity [−]
εo permittivity [−]
ε dissipation [m 2/s3]
η damping coefficient, Kolmogorov length scale [m]
ηi impact efficiency [−]
Θ granular temperature [m 2/s2]
κ coefficient for conductivity of granular temperature [kg/ms]
λ mean free path [m], evaporation constant [m 2/s], burning rate [m 2/s];
λt viscosity ratio [−].
Thermal slip parameter []
μ mean value, viscosity [N · s/m 2]
μs solids phase shear viscosity [N · s/m 2]
µ viscosity ratio [−]
ν kinematic viscosity [m 2/s]
νs subgrid kinematic viscosity [m 2/s]
νT turbulent kinematic viscosity [m 2/s]
Ξ dimensionless distance related to boundary [-]
Nomenclature xvii
SUBSCRIPTS
c continuous phase, carrier phase
cl center line
C Collision
d dispersed phase, droplet phase
e effective
E Emitter
II Parallel
m pertains to mass; pertains to film coefficients
n Number
p pressure, computational particle
r radiation, receiver
R rotation
s particle surface
t Tangential
tp transverse, perpendicular
T thermophoresis
SS steady state
∞ far from the particle surface
xviii Nomenclature
OPERATORS
() time average
xix
About the Authors
Efstathios E. (Stathis) Michaelides, PhD, is currently the holder of W.A. (Tex)
Moncrief Chair of Engineering at Texas Christian University (TCU) and also
a Fellow of the Ralf Lowe Energy Institute at TCU. He is recognized as a lead-
ing scholar in the areas of multiphase flows and energy conversion, where he has
authored seven monographs. He has published more than 170 journal papers and has
contributed more than 250 presentations in national and international conferences.
He chaired the Fourth International Conference on Multiphase Flows (New Orleans
May 27 to June 1, 2001). He was awarded an honorary M.A. degree from Oxford
University (1983); the ASEE Centennial Award for Exceptional Contributions to the
Profession of Engineering (1993); the Lee H. Johnson award for Teaching Excellence
(1995); the Senior Fulbright Fellowship (1997); the ASME Freeman Scholar award
(2002); the Outstanding Researcher award at Tulane University (2003); the ASME
Outstanding Service award (2007); the ASME Fluids Engineering award (2014); the
ASME-FED Ninetieth Anniversary Medal (2016); and the ASME Edwin F. Church
Medal for “eminent service in increasing the value, importance and attractiveness
of mechanical engineering education.”
xxi
xxii About the Authors
xxiii
1 Introduction
The flow of particles and droplets in fluids is a category of multiphase flows, often
involving multiple components. A component is a chemical species such as nitrogen,
oxygen, water, iron, carbon, or Freon-134a. A phase refers to the solid, liquid, and
vapor state of the matter. The flow of multicomponent, multiphase mixtures covers
a wide spectrum of applications and flow conditions with some examples of single
and multicomponent, multiphase flows listed in Table 1.1.
Although air is composed of several components, it is common practice to con-
sider the ambient air at temperatures below 2,000 K as a single component (79%
nitrogen and 21% oxygen) and assign to it unique thermodynamic (e.g. enthalpy,
entropy, specific heat capacity, etc.) and transport (e.g. viscosity, thermal conductiv-
ity, diffusivity, etc.) properties. Air is treated as a multicomponent mixture at higher
temperatures, where dissociation occurs, and at cryogenic temperatures, where
some of its constituent species may condense.
The flow of mixtures of liquids is also an important industrial application. For
example, water and supercritical carbon dioxide are often used to flush petroleum
from wells (secondary and tertiary oil recovery), a process that gives rise to a multi-
component single- or multiphase flow. If the two liquids are miscible (e.g. water and
ethyl alcohol), then the homogeneous mixture is commonly treated as a single-phase
with modified properties. If the liquids are immiscible (e.g. oil and water), then
the liquid cannot be regarded as homogeneous, and treatment of the flow problem
becomes much more complex. In this situation, one may have “globs,” or drops of oil
in the water, or (at high oil content) “globs,” or drops of water carried in a continuous
matrix of oil. The mixtures of two liquids are generally referred to as emulsions.
Single-component, multiphase flows are typically the flow of a liquid with its
vapor. The most common example is steam-water flows, which are found in a wide
variety of industries. Another example of single-component, multiphase flows are
refrigerants in a refrigeration system.
The flow of fluids of a single phase has occupied the attention of scientists and
engineers for many years. The equations for the motion and thermal properties of
single-phase fluids are well accepted (Navier-Stokes equations), and closed-form
TABLE 1.1
Examples of Single and Multicomponent, Multiphase Flows
Single component Multicomponent
Single-phase Water flow Combustion gases
Nitrogen flow Flow of oil-water emulsions
Multiphase Steam-water flow Air-water flow
Freon-Freon liquid-vapor flow Coal slurry flow
DOI: 10.1201/9781003089278-1 1
2 Multiphase Flows with Droplets and Particles
solutions for specific cases are well documented. A major difficulty is the model-
ling and quantification of turbulence and its influence on mass, momentum, and
energy transfer. The state-of-the art for multiphase flow models is considerably more
primitive in that the correct formulation of the governing equations is still subject to
debate. For this reason, the study of multiphase flows represents a challenging and
potentially fruitful area of endeavor for the scientist or engineer.
Multiphase flows can be subdivided into four categories: Gas-liquid, gas-solid,
liquid-solid, and three-phase flows. Examples of these four categories are shown in
Table 1.2. A gas-liquid flow can assume several different configurations. For exam-
ple, the motion of bubbles in a liquid, in which the liquid is the continuous phase is a
gas-liquid flow. On the other hand, the motion of liquid droplets in a gas is also a gas-
liquid flow. In this case, the gas is the continuous phase. Also, a separated flow, in
which the liquid moves along the bottom of a pipe and the gas along the top is also a
gas-liquid flow. In this situation, both phases are continuous. The first two examples,
bubbles in a liquid and droplets in a gas, are known as dispersed phase flows since
one phase is dispersed, and the other is continuous. By definition, one can pass from
one point to another in the continuous phase while remaining in the same medium.
One cannot pass from one droplet to another without going through the gas.
Gas-solid flows are usually considered to be a gas with dispersed and suspended
solid particles. This category includes pneumatic transport as well as fluidized
beds. Another example of a gas-solid flow is the motion of particles down a chute or
inclined plane. These are known as granular flows. Particle-particle and particle-wall
interactions are much more important than the forces due to the interstitial gas. If the
particles become motionless, the problem reduces to flow through a porous medium
in which the viscous force on the particle surfaces is the primary mechanism affect-
ing the gas flow. An example is a pebble-bed heat exchanger. It is not appropriate to
refer to flow in a porous medium as a gas-solid flow since the solid phase is not in
motion. Gas-solid flow is another example of a dispersed phase flow since the par-
ticles constitute the dispersed phase, and the gas is the continuous phase.
Liquid-solid flows consist of flows in which solid particles are carried by the
liquid and are referred to as slurry flows. Slurry flows cover a wide spectrum of
TABLE 1.2
Categories of Multiphase Flows
Gas-liquid flows Bubbly flows
Separated flows
Gas-droplet flows
Gas-solid flows Gas-particle flows
Pneumatic transport
Fluidized beds
Liquid-solid flows Slurry flows
Hydrotransport
Sediment transport
Three-phase flows Bubbles in a slurry flow
Droplets/particles in gaseous flows
Introduction 3
applications from the transport of coals and ores to the flow of mud. These flows can
also be classified as dispersed phase flows and are the focus of considerable interest
in engineering research. Once again it is not appropriate to refer to the motion of
liquid through a porous medium as a liquid-solid flow since the solid phase is not in
motion.
Three-phase flows are also encountered in engineering problems. For example,
bubbles in a slurry flow give rise to the presence of three phases flowing together.
There is little work reported in the literature on three-phase flows.
The subject of this book is the flow of particles or droplets in a fluid, specifically
the flow of particles and/or droplets in a conveying gas as well as particles in a con-
veying liquid. The other area of dispersed phase flows, namely, bubbly flows, will
not be addressed here. Particulate flows—a term that includes the flows of particles
and drops in fluids—has a wide application in industrial, energy generation, and
environmental processes: The removal of particulate material from exhaust gases
is essential to the control of pollutants generated by power plants fired by fossil
fuels. The efficient combustion of droplets and coal particles in a furnace depends
on the multiple interactions of particles or droplets with air. Some food produc-
tion depends on the drying of liquid droplets to powders in high-temperature gas
streams. The transport of powders in pipes is common to many chemical and pro-
cessing industries.
For many years, the design of systems with particles and droplets was based pri-
marily on empiricism. Since the 1980s, more sophisticated measurement techniques
have led to improved process control and evaluation of fundamental parameters.
Increased computational capability has enabled the development of numerical mod-
els that can be used to complement engineering system design. The improved under-
standing of this engineering subject is a rapidly growing field of technology, which
has far-reaching benefits in upgrading the operation and efficiency of processes,
in system optimization, and in supporting the development of new and innovative
approaches. A great deal more material in multiphase flows and the current status
of multiphase flow technology in industrial applications can be found in the second
edition of the Multiphase Flow Handbook (Michaelides et al., 2017).
gases. The droplets are dried, and their solid content forms a powder. The general
configuration of a countercurrent flow spray dryer is shown in Figure 1.1. A slurry
or concentrated mixture is introduced at the top of the dryer and atomized into
droplets. Hot gases are fed into the bottom with a swirl component and move upward
through the dryer. The droplets are dried as they fall through the hot rising gases to
form a powder, which is collected by precipitation at the bottom and removed as the
final product.
The gas-droplet (particle) flow within the dryer is very complex. The swirling
motion of the gases transports the particles toward the wall, and this may lead to
impingement and accumulation. The temperature distribution in the dryer will
depend on the local concentration of the droplets as they fall through the dryer. High
local concentrations will depress the local gas temperature and lead to less effective
drying. The result may be a non-uniformly dried product reducing product quality.
In practical driers, accumulation of the dried product on the wall is to be avoided
because of uncontrolled drying, material degradation, and the possibility of fire.
Also, in the case of food production, the product cannot become too hot to avoid
altering any proteins or other ingredients and jeopardizing its nutritional value or
its taste.
Even though spray drying technology has been continuously improved through
the years, it is still difficult to scale up models to prototype operation. It is also
difficult to determine, without actual testing, how modifying the design of a con-
ventional dryer will affect performance. There has been significant progress
Introduction 5
(Verdurmen et al., 2004, 2005) in the development of numerical and analytic tools
that adequately simulate the gas-droplet flow field in the dryer. Such models and
the pertinent analyses, which require sophisticated modelling techniques, could be
effectively used to improve the efficiency of current driers, optimize their design,
predict off-design performance, and serve as a tool for scale-up of promising bench-
scale designs to prototype operation.
loss) and the solids loading are higher. The lower velocity leads to less material
degradation and line erosion.
Many studies on pressure drop in pneumatic transport have been reported, but
there are considerable discrepancies in the reported data. The discrepancies are
primarily due to the different nature of the solid particles and the particle-wall
collisions, which are affected by the particles’ inertia, turbulence, particle shapes,
and wall roughness (Michaelides and Roy, 1987; Michaelides, 1987; Sommerfeld
and Lain, 2015). Extensive experience with the design, installation, and operation
of pneumatic transport systems has given rise to design criteria, which ensure
a functional system. In dense-phase transport, the pressure drop is proportional
to the square of the length of the slug, so various schemes have been devised to
achieve this end. Still, there are situations where extensive experience is insuf-
ficient. One such case is the transport of wet particles, for which little information
is available on the tendency of the particles to stick together, to accumulate on the
wall or in bends, and to plug the pipe. Even more fundamental, there is essentially
no information on the pressure drop associated with the conveying of the dif-
ferent types of wet solids. Hence, even simple conveying of particles comprises
numerous elementary particle-scale processes, which need to be considered, such
as fluid forces on non-spherical particles, inter-particle collisions and long-term
particle contacts, wall collisions associated with possible particle degradation,
erosion, and deposition.
edge of the spray will cool faster than those near the core. The understanding and
ability to predict the movement and thermal behavior of the droplets in the spray
is important to the continued development and optimization of the spray forming
process.
material (usually garnet) in the jet enables cutting of hard materials, such as con-
crete and glass. The effectiveness of the abrasive water jet depends on the speed
with which the abrasive material impacts the surface. The particles of the abrasive
material are accelerated by the drag of the fluid, which is an intriguing multiphase
flow problem.
than 200 nm and can be produced by the compaction of noncrystalline materials. One
approach that has been investigated to produce nanoclusters is gas phase synthesis.
A second technique is the injection of precursor materials into diffusion or premixed
flames, where the formed particle sizes are in the range 1 to 500 nanometers. The wide
range of sizes results from the lack of control of the steep thermal gradients. A third
approach is with thermal reactors, in which the precursor materials are introduced
into the furnace in the form of an aerosol. Chemical reactions occur as the multiphase
mixture passes through the furnace. The control of particle size is highly dependent
on the regulation of temperature and flow velocity. This represents an important appli-
cation of multiphase flows, in which thermal coupling between the gaseous and par-
ticulate phases is critical for the quality of the formed material. Spray pyrolysis is also
being used in connection with furnace reactors, in which a precursor is atomized and
advected through the furnace. The solvent evaporates and reactions occur between
the multitude of particles to form the desired material. The last approach is promising
because of the possibility of making multicomponent materials. It is important in this
approach to control the temperature, the velocity, and the residence time of the par-
ticles in the furnace, a challenging problem in multiphase flow technology.
most of the particles. At a given flow rate, “bubbles”—regions of low particle den-
sity—appear in the fluidized bed and rise through the bed, thus intensifying the
mixing within the bed. Fluidized beds are used for many chemical processes, such
as coal gasification, combustion, liquefaction, as well as the disposal of organic,
biological, and toxic wastes.
12 Multiphase Flows with Droplets and Particles
Currently the design and operation of a fluidized bed is the result of many years
of experience in building, modifying, and testing to achieve the best performance
possible. The mechanics of the multiphase flow in a fluidized bed has been, and
continues to be, a challenge to the scientist and practicing engineer. Some have cho-
sen to treat this flow as a homogeneous fluid with a modified viscosity and thermal
conductivity. Others have modeled the problem using the discrete particle approach,
in which the motion of each particle is considered. The former approach depends on
developing appropriate relationships for the transport properties of the particulate
phase. The latter approach requires extensive computer capability to include a suffi-
cient number of particles to simulate the heterogeneous system (Michaelides, 2013).
Even though the numerical models for multiphase flow in a fluidized bed appear
promising, there are still many issues that have to be included, such as the cohesive-
ness of particles, the sticking probability of wet particles, as well as particle-wall
interactions.
collected. For very fine particles (less than 50 microns), the cyclone separator, which
is schematically shown in Figure 1.9, is used. The gas-particle flow enters the device
in a tangential direction at the top of the separator. The resulting vortex motion and
the centrifugal force in the separator causes the particles to migrate toward the wall.
Gravity and secondary flows drive the particles to the bottom of the cyclone, where
they are collected in a bin. The gases converge toward the center and form a vortex
flow, which exits through a pipe at the top of the cyclone body. The performance
of the cyclone is quantified by the particle “cut size”—the particle diameter above
which all the particles are collected. This value may be obtained through a simple
model based on comparisons of the centrifugal force with the inward directed radial
drag force at the imaginary surface of a cylinder extending between outlet pipe
and cyclone bottom. Years of experience in cyclone separator design have resulted
in “standard” designs that, under normal operating conditions, have predictable
performance. Numerical modelling and other analytical approaches are needed to
design cyclones for special applications, such as hot-gas cleanup. Particle behavior
in cyclone separators is strongly affected by wall collisions, inter-particle collisions,
and possible agglomeration. Figure 1.10 shows the results of a numerical simulation
using the Euler/Lagrange approach, which considers four different modelling levels.
A snapshot of the near-wall particle concentration is shown exhibiting the typical
spiral downward transport of the particle in strands or ropes. Two-way coupling
(2-WC) implied passive transport of the particles and four-way coupling includes
the influence of the particle phase on the fluid flow. The right two graphs are results
obtained by different particle agglomeration models (sphere model implies that new
agglomerates are treated as volume equivalent spheres, and history models account
14 Multiphase Flows with Droplets and Particles
FIGURE 1.10 Distribution of particle concentration within the cyclone body near the walls,
obtained by numerical Euler/Lagrange simulations.
for the temporal evolution of porosity during the agglomeration process). It is obvi-
ous that the near wall particle concentration and the rope development is completely
different in the four modelling cases (Sgrott et al., 2019).
FIGURE 1.12 Numerically simulated flow field (coupled flow and electric field) and particle
motion through an electrostatic precipitator (a) flow field through the channel in the initial
part showing streamlines and electric field strength as gray scale; (b) trajectories of particles
with diameters between 0.9 and 1.5 μm; (c) trajectories of particles with diameters between
12 and 20 μm. The inflow velocity is 0.5 m/s, the applied voltage 60 kV, negative corona,
initial particle charge 66% of full charge.
16 Multiphase Flows with Droplets and Particles
obviously influences the particle concentration and the charge density. These, in
turn, affect the electric field. Flow turbulence is also introduced by the structural
ribs in the system and the corona discharge. The effects of turbulence are visible in
the calculated particle trajectories (parts b and c), where the smaller particles exhibit
stronger fluctuations. The larger particles are faster separated due to their higher
level of charging, as shown in part c of the figure.
1.3.1.3 Scrubbers
Another pollution control device is the wet gas scrubber, which is designed to
remove particulate as well as gaseous pollutants. Scrubbers come in many configu-
rations and the venturi scrubber, shown in Figure 1.13, represents one of the simple
designs. Liquid (atomized by the airstream) or droplets are introduced upstream of
the venturi or in the narrow throat, and then the particles carried in the flue gas are
captured by the droplets. The process of particle-droplet collisions is very important
at this stage. The collision rate depends mainly on the droplet and particle concen-
trations, as well as the relative velocity between them. During this interaction, the
impact efficiency is important since the particles are normally much smaller than
the droplets and may bypass the droplet with the relative flow yielding no collision.
Therefore, the size ratio needs to be properly adapted in order to provide sufficiently
high collision rates. The droplets, being much larger than the particles, can be more
easily separated from the flow.
Sulfur dioxide gas is also removed from the combustion products in coal power
plants by using a “shower” of water droplets mixed with lime. The sulfur dioxide
is absorbed on the surface of the droplets and reacts with the lime to form CaSO3,
which is a solid. The droplets are collected in tanks by precipitation, and then the
solid CaSO3 particles also precipitate in the aqueous solution and are removed. The
remaining water is reused to generate droplets in the scrubber.
flux per unit area (required delivery density) to extinguish the fire. This design cri-
terion is generally established by experiment. The phenomena associated with the
spray are complex. As the droplets are projected toward the fire, they are evaporated
by the hot gases and may not penetrate to reach the location of the fire. The evapo-
rating droplets also cool the gases and reduce the radiative thermal feedback to the
flame. Modelling fire suppression by droplets is an active area of research.
(pMDI); (b) the dry powder inhaler (DPI); and (c) the soft mist inhaler (SMI) oper-
ating with a pressurized spray. Dry powder inhalers are low-cost, cheap, and flex-
ible devices, which are easy to use for delivering particulate drugs directly to the
lung. However, in DPI applications, only about 30%–50% of the loaded dose reaches
deep into the lung and is effectively deposited. The active pharmaceutical ingredi-
ent (API) particles that can be administered via dry powder inhalers have to exhibit
aerodynamic particle diameters in the size range up to about 5 μm, as only particles
of this size range can reach the tiny airways of the deep lung. The performance and
efficiency of DPIs is strongly related to the way of drug delivery and the API formu-
lations being used (Daniher and Zhu, 2008).
There are three kinds of dry powder inhalers that are classified based on the
drug powder delivery, namely, single-dose inhalers, multi-unit dose inhalers, and
reservoir-based systems. In the case of single-dose inhalers, the required amount of
API is loaded into capsules or blisters, which then, before the inhalation, are placed
into the inhaler and then pricked by needles or broken in order to release the drug
formulation. Very specific ways of drug powder delivery is done for multi-unit-dose
devices by a rotating disk or multiple blisters. Finally, reservoir inhaler types have
a powder storage with hundreds of doses. Just prior to inhalation, one dose is trans-
ported into a small pre-chamber, wherefrom the powder dose is withdrawn by the
breathing airstream (Daniher and Zhu, 2008).
The most frequently found drug formulations in dry powder inhalers are carrier-
based systems (i.e. the drug powder is blended with larger carrier particles in a
mixer, normally with carrier diameters between about 50 µm to 200 µm, so that the
fine drug particles are homogeneously distributed on the carrier surface). On the
other hand, a fine API powder may be used directly.
The inhaler should perform in such a way that the drugs are detached from the
carrier, or if drug agglomerates exist, they are destroyed (also called aerosolization).
These processes essentially determine the inhaler efficiency, characterized by the
fine particle fraction (FPF) being eventually delivered to the lung airways. Hence,
in order to deliver a high amount of fine drug particles, a proper balancing of the
adhesive forces between carrier and drug particles and the removal forces during
the inhalation process is necessary. This also applies to the adhesion among drug
particles in situations where they form clusters and agglomerates. Thus, adhesive
interactions between API particles and between carrier particles and API play a key
role in these kind of formulations (Cui et al., 2014; Zellnitz et al., 2015).
The flow structure inside inhalers is mostly very complex and highly turbulent
depending on the design, and there are numerous designs available on the market
(Islam and Cleary, 2012). The typical maximum inhalation flow rate is about 70 L/
min, depending on the health conditions and the age of the patient. Aerosolization
of the drugs may be realized by fluid stresses induced by the breathing airflow or
collisions with device walls. The fluid dynamic detachment of drug powder from a
carrier (or the breakage of agglomerates) in the very complex airflow of inhalers is
realized by acceleration/deceleration of the clusters (i.e. inertial forces), flow shear
gradients, and turbulent stresses (Telko and Hickey, 2005). Drug detachment or
agglomerate breakage during wall impact is mainly caused by inertial effects,
which depend on impact velocity and angle (Yang et al., 2015; Ariane et al., 2018).
Introduction 19
If aerosolization does not take place, the drug particles sticking on the carrier
surface or existing in agglomerated form will deposit together in the mouth and
throat region.
The deposition of fine drug powder on the inhaler walls may constitute a problem
and reduce the emitted fine particle dose. For this reason, and for the understanding
of the processes within inhalers as a basis for optimization, CFD (computational
fluid dynamics) has been applied to dry powder inhalers in the last fifteen years.
A typical capsule-based swirl-type inhaler is shown in Figure 1.15 together
with a steady-state RANS (Reynolds-Averaged-Navier-Stokes) solution of the
complex flow field within the inhaler at a flow rate of 70 L/min (Sommerfeld
et al., 2019). In this single-dose inhaler, the capsule with the required dose of
API is initially placed in the capsule chamber and, just before breathing, is
pricked from the side faces with needles to allow drug release. When breathing
starts, the flow enters from the outside through two tangential inlets into the
swirl chamber, inducing a strongly swirling flow that can easily reach 50 m/s.
With this flow, the capsule is lifted and begins to rotate, releasing the powder
through the holes in the caps of the capsule. These particles will, depending on
their size, frequently collide with the walls (Sommerfeld et al., 2019) and are
carried through the grid and the mouthpiece, eventually entering the oral cavity
and lung airways of a human. The grid causes particle-wall collisions inducing
dispersion and daps the swirling motion to avoid particle-wall collisions in the
mouthpiece and have a pressure recovery. Consequently, the flow in inhalers is
very complex, and particle transport is affected by numerous elementary pro-
cesses, including wall collisions, inter-particle collisions, de-agglomeration, and
a possible wall deposition.
FIGURE 1.16 Anatomical regions of the complete human pulmonary system and airway
generation model.
Introduction 21
Article I
For the purpose of maintaining a permanent and solid friendship
between Japan and Korea, and firmly establishing peace in the Far
East, the Imperial Government of Korea shall place full confidence in
the Imperial Government of Japan and adopt the advice of the latter
in regard to improvements in administration.
Article II
The Imperial Government of Japan shall in a spirit of firm
friendship ensure the safety and repose of the Imperial House of
Korea.
Article III
The Imperial Government of Japan definitely guarantees the
independence and territorial integrity of the Korean Empire.
Article IV
In case the welfare of the Imperial House of Korea or the territorial
integrity of Korea is endangered by aggression of a third Power or
internal disturbances, the Imperial Government of Japan shall
immediately take such necessary measures as the circumstances
require; and in such cases the Imperial Government of Korea shall
give full facilities to promote the action of the Imperial Japanese
Government.
The Imperial Government of Japan may, for the attainment of the
above-mentioned object, occupy, when the circumstances require it,
such places as may be necessary from strategical points of view.
Article V
The Governments of the two countries shall not in future, without
mutual consent, conclude with a third Power such an arrangement
as may be contrary to the principles of the present Protocol.
Article VI
Details in connection with the present Protocol shall be arranged
as the circumstances may require between the Representative of
Japan and the Minister of State for Foreign Affairs of Korea.
APPENDIX B
PROTOCOL SIGNED AUGUST 22, 1904
Article I
The Korean Government shall engage as Financial Adviser to the
Korean Government, a Japanese subject recommended by the
Japanese Government, and all matters concerning finance shall be
dealt with after his counsel being taken.
Article II
The Korean Government shall engage as diplomatic adviser to the
Department of Foreign Affairs, a foreigner recommended by the
Japanese Government, and all important matters concerning foreign
relations shall be dealt with after his counsel being taken.
Article III
The Korean Government shall previously consult the Japanese
Government in concluding treaties and conventions with foreign
Powers, and in dealing with other important diplomatic affairs, such
as the grant of concessions to, or contracts with, foreigners.
APPENDIX C
CONVENTION OF JULY 24, 1907