AMPK activators: mechanisms of action and physiological activities (Q26749158)

2

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Yeji Kim

3

0 references

Jin Kim

4

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Joohun Ha

Experimental and Molecular Medicine

5

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language of work or name

English

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publication date

2016

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1 April 2016

2 references

28 September 2019

20 November 2019

3 references

28 September 2019

20 November 2019

48

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issue

4

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page(s)

e224

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copyright license

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International

2 references

Europe PubMed Central

28 September 2019

Europe PubMed Central

The ancient drug salicylate directly activates AMP-activated protein kinase

20 November 2019

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Structure of mammalian AMPK and its regulation by ADP

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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Structural basis for AMP binding to mammalian AMP-activated protein kinase

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AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

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Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

7 April 2017

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Role of AMP-activated protein kinase in mechanism of metformin action

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The regulation of AMP-activated protein kinase by phosphorylation

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Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators

28 September 2017

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Structural basis of AMPK regulation by small molecule activators

7 April 2017

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Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols

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Resveratrol improves health and survival of mice on a high-calorie diet

7 April 2017

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TSC2 mediates cellular energy response to control cell growth and survival

7 April 2017

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Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy

7 April 2017

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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

7 April 2017

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

7 April 2017

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CBS domains: structure, function, and pathology in human proteins

7 April 2017

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Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

7 April 2017

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Autophagy and the Integrated Stress Response

7 April 2017

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Regulation mechanisms and signaling pathways of autophagy

7 April 2017

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Autophagy regulates lipid metabolism

7 April 2017

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

7 April 2017

1 reference

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

7 April 2017

1 reference

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Autophagy in mammalian development and differentiation

7 April 2017

1 reference

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

7 April 2017

1 reference

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

7 April 2017

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Metformin and reduced risk of cancer in diabetic patients

7 April 2017

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

7 April 2017

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5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

7 April 2017

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

7 April 2017

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AMPK and autophagy in glucose/glycogen metabolism

7 April 2017

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Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis.

28 September 2017

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Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.

28 September 2017

1 reference

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Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

28 September 2017

1 reference

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PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

28 September 2017

1 reference

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Screening methods for AMP-activated protein kinase modulators: a patent review

28 September 2017

1 reference

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Metabolic control of autophagy

28 September 2017

1 reference

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Metformin: from mechanisms of action to therapies

28 September 2017

1 reference

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AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

28 September 2017

1 reference

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Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK

28 September 2017

1 reference

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A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis

28 September 2017

1 reference

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AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels

28 September 2017

1 reference

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AMP-activated protein kinase: An emerging target for ginseng

28 September 2017

1 reference

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Role of AMP-activated protein kinase in cancer therapy

28 September 2017

1 reference

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A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

28 September 2017

1 reference

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AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation

28 September 2017

1 reference

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Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis

28 September 2017

1 reference

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Advances in the development of AMPK-activating compounds

28 September 2017

1 reference

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Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats

28 September 2017

1 reference

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Direct AMP-activated protein kinase activators: a review of evidence from the patent literature

28 September 2017

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Lipid metabolism in cancer

28 September 2017

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AMPK functions as an adenylate charge-regulated protein kinase.

28 September 2017

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Diabetes and alpha lipoic Acid.

28 September 2017

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New and emerging agents for the treatment of castration-resistant prostate cancer

28 September 2017

1 reference

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AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy

28 September 2017

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AMP-activated protein kinase modulators: a patent review (2006 - 2010).

28 September 2017

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Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism.

28 September 2017

1 reference

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Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

28 September 2017

1 reference

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New strategies in prostate cancer: targeting lipogenic pathways and the energy sensor AMPK

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Autophagy regulates adipose mass and differentiation in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

28 September 2017

1 reference

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Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis.

28 September 2017

1 reference

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AMPK: a key regulator of energy balance in the single cell and the whole organism.

28 September 2017

1 reference

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A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

28 September 2017

1 reference

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Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

28 September 2017

1 reference

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Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

28 September 2017

1 reference

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Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53.

28 September 2017

1 reference

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Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

AMP-activated protein kinase as a drug target.

28 September 2017

1 reference

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Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

LKB1-dependent signaling pathways

28 September 2017

1 reference

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Mitochondria as signaling organelles in the vascular endothelium

28 September 2017

1 reference

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AMP-activated protein kinase and type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

28 September 2017

1 reference

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AMP-activated protein kinase: a master switch in glucose and lipid metabolism.

28 September 2017

1 reference

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Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes

28 September 2017

1 reference

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The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

The molecular basis and clinical aspects of Peutz-Jeghers syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

The regulation of AMP-activated protein kinase by H(2)O(2).

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

Inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855276

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

31 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

AMPK is a direct adenylate charge-regulated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Salicylate acutely stimulates 5'-AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27034026

12 December 2020

inferred from PubMed ID database lookup

Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27034026

12 December 2020

inferred from PubMed ID database lookup

5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27034026

12 December 2020

inferred from PubMed ID database lookup

An antibody VH domain with a lox-Cre site integrated into its coding region: bacterial recombination within a single polypeptide chain

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2016.16

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/EMM.2016.16

1 reference

Dimensions Publication ID

1050471096

0 references

1 reference

1 reference

PubMed publication ID

27034026

1 reference