세린 레이스마아제 는 L-세린에서 D-세린 을 생성하는 효소 다.디세린은 뇌에서 NMDA 수용체 를 활성화시켜 뉴런 신호 분자의 역할을 한다. 인간에서 세린 레이스마제 단백질 은 SRR 유전자 에 의해 암호화된다.[5]
포유류 세린 레이스마아제는 피리독살 5'인산염 의존 효소로, L-세린 에서 D-세린까지의 레이싱화 와 더불어 L-세린에서 수분 제거를 촉진하여 피루바이트 와 암모니아 를 발생시킨다.[6] 효소는 생리학적으로 분열된 양이온(예: 마그네슘 )에 의해 자극되어 마그네슘에 의해 알로스테리릭적으로 활성화된다. ATP 콤플렉스.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000167720 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000001323 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ De Miranda J, Santoro A, Engelender S, Wolosker H (Oct 2000). "Human serine racemase: moleular cloning, genomic organization and functional analysis". Gene . 256 (1–2): 183–8. doi :10.1016/S0378-1119(00)00356-5 . PMID 11054547 . ^ De Miranda J, Panizzutti R, Foltyn VN, Wolosker H (Oct 2002). "Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine" . Proceedings of the National Academy of Sciences of the United States of America . 99 (22): 14542–7. Bibcode :2002PNAS...9914542D . doi :10.1073/pnas.222421299 PMC 137919 PMID 12393813 . 추가 읽기 Morita Y, Ujike H, Tanaka Y, Otani K, Kishimoto M, Morio A, Kotaka T, Okahisa Y, Matsushita M, Morikawa A, Hamase K, Zaitsu K, Kuroda S (May 2007). "A genetic variant of the serine racemase gene is associated with schizophrenia" . Biological Psychiatry . 61 (10): 1200–3. doi :10.1016/j.biopsych.2006.07.025 . PMID 17067558 . S2CID 8142062 . Steffek AE, Haroutunian V, Meador-Woodruff JH (Jul 2006). "Serine racemase protein expression in cortex and hippocampus in schizophrenia". NeuroReport . 17 (11): 1181–5. doi :10.1097/01.wnr.0000230512.01339.72 . PMID 16837850 . S2CID 35663584 . Fujii K, Maeda K, Hikida T, Mustafa AK, Balkissoon R, Xia J, Yamada T, Ozeki Y, Kawahara R, Okawa M, Huganir RL, Ujike H, Snyder SH, Sawa A (Feb 2006). "Serine racemase binds to PICK1: potential relevance to schizophrenia" . Molecular Psychiatry . 11 (2): 150–7. doi :10.1038/sj.mp.4001776 PMID 16314870 . Dumin E, Bendikov I, Foltyn VN, Misumi Y, Ikehara Y, Kartvelishvily E, Wolosker H (Jul 2006). "Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase" . The Journal of Biological Chemistry . 281 (29): 20291–302. doi :10.1074/jbc.M601971200 PMID 16714286 . Strísovský K, Jirásková J, Barinka C, Majer P, Rojas C, Slusher BS, Konvalinka J (Jan 2003). "Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate". FEBS Letters . 535 (1–3): 44–8. doi :10.1016/s0014-5793(02)03855-3 . PMID 12560076 . S2CID 43772379 . Hoffman HE, Jirásková J, Ingr M, Zvelebil M, Konvalinka J (Jan 2009). "Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog". Protein Expression and Purification . 63 (1): 62–7. doi :10.1016/j.pep.2008.09.003 . PMID 18812225 . Sarras H, Semeralul MO, Fadel MP, Feldcamp LA, Labrie V, Wong AH (Jul 2010). "Elevated PICK1 mRNA in schizophrenia increased SRR mRNA in suicide". Schizophrenia Research . 120 (1–3): 236–7. doi :10.1016/j.schres.2010.03.002 . PMID 20385472 . S2CID 21820692 . Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, Okuno A, Takao H, Toyota T, Minabe Y, Nakamura K, Shimizu E, Itokawa M, Mori N, Iyo M, Yoshikawa T (Jun 2005). "Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels". Biological Psychiatry . 57 (12): 1493–503. doi :10.1016/j.biopsych.2005.03.018 . PMID 15953485 . S2CID 22811942 . Xia M, Liu Y, Figueroa DJ, Chiu CS, Wei N, Lawlor AM, Lu P, Sur C, Koblan KS, Connolly TM (Jun 2004). "Characterization and localization of a human serine racemase". Brain Research. Molecular Brain Research . 125 (1–2): 96–104. doi :10.1016/j.molbrainres.2004.03.007 . PMID 15193426 .
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