Biology:ETV4
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.[1][2][3]
Disease marker
Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma. While both are cancerous tumors, the former grows in the bones most commonly affecting the arms, legs, hips, and spine, while the later affects the soft tissue in the chest, foot, pelvis and spine.
References
- ↑ "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics 28 (2): 357–9. Jul 1995. doi:10.1006/geno.1995.1158. PMID 8530053.
- ↑ "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2118.
- ↑ "ETV4 Gene - GeneCards | ETV4 Protein | ETV4 Antibody". https://www.genecards.org/cgi-bin/carddisp.pl?gene=ETV4.
Further reading
- "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors". Genomics 25 (1): 256–63. Jan 1995. doi:10.1016/0888-7543(95)80133-7. PMID 7774926.
- "Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor". Developmental Genetics 16 (3): 229–40. 1995. doi:10.1002/dvg.1020160303. PMID 7796532.
- "The search for BRCA1". Cancer Research 54 (24): 6374–82. Dec 1994. PMID 7987831.
- "Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family". Nucleic Acids Research 21 (3): 547–53. Feb 1993. doi:10.1093/nar/21.3.547. PMID 8441666.
- "A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma". Biochemical and Biophysical Research Communications 219 (2): 608–12. Feb 1996. doi:10.1006/bbrc.1996.0281. PMID 8605035.
- "Genomic organization of the human e1af gene,a member of Ets transcription factors". Gene 240 (1): 201–7. Nov 1999. doi:10.1016/S0378-1119(99)00400-X. PMID 10564827.
- "A novel zinc finger gene is fused to EWS in small round cell tumor". Oncogene 19 (33): 3799–804. Aug 2000. doi:10.1038/sj.onc.1203762. PMID 10949935.
- "PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma". Clinical Cancer Research 9 (4): 1412–9. Apr 2003. PMID 12684413.
- "E1AF expression levels are not associated with prognosis in human breast cancer". Breast Cancer Research and Treatment 79 (1): 129–31. May 2003. doi:10.1023/A:1023338424677. PMID 12779089.
- "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics 3 (4): 311–26. Apr 2004. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
- "Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells". The Journal of Biological Chemistry 279 (18): 18694–700. Apr 2004. doi:10.1074/jbc.M308136200. PMID 14976201.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions". Clinical & Experimental Metastasis 21 (3): 191–9. 2004. doi:10.1023/B:CLIN.0000037703.37275.35. PMID 15387369.
- "The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells". The Biochemical Journal 386 (Pt 1): 35–45. Feb 2005. doi:10.1042/BJ20040706. PMID 15461591.
- "Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator". The Journal of Biological Chemistry 280 (13): 12503–16. Apr 2005. doi:10.1074/jbc.M413631200. PMID 15611127.
- "E1AF degradation by a ubiquitin-proteasome pathway". Biochemical and Biophysical Research Communications 327 (2): 575–80. Feb 2005. doi:10.1016/j.bbrc.2004.12.045. PMID 15629152.
- "Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis". Carcinogenesis 26 (5): 892–9. May 2005. doi:10.1093/carcin/bgi029. PMID 15695237.
External links
- ETV4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P43268 (ETS translocation variant 4) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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