Biology:ING4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.

Function

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.

Interactions

ING4 has been shown to interact with EP300, RELA and P53.

Further reading

• "Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4". Cell Cycle 4 (9): 1153–6. September 2005. doi:10.4161/cc.4.9.2040. PMID 16096374. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America 97 (17): 9543–8. August 2000. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H. 
• "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis". Nature 428 (6980): 328–32. March 2004. doi:10.1038/nature02329. PMID 15029197. Bibcode: 2004Natur.428..328G. 
• "ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells". FEBS Letters 570 (1–3): 7–12. July 2004. doi:10.1016/j.febslet.2004.06.010. PMID 15251430. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research 14 (10B): 2121–7. October 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer". Proceedings of the National Academy of Sciences of the United States of America 101 (46): 16251–6. November 2004. doi:10.1073/pnas.0407158101. PMID 15528276. Bibcode: 2004PNAS..10116251K. 
• "Nuclear localization signal of ING4 plays a key role in its binding to p53". Biochemical and Biophysical Research Communications 331 (4): 1032–8. June 2005. doi:10.1016/j.bbrc.2005.04.023. PMID 15882981. 
• "The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)". Proceedings of the National Academy of Sciences of the United States of America 102 (21): 7481–6. May 2005. doi:10.1073/pnas.0502716102. PMID 15897452. Bibcode: 2005PNAS..102.7481O. 
• "Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas". Gene 356: 109–17. August 2005. doi:10.1016/j.gene.2005.02.014. PMID 15935570. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Molecular Cell 23 (4): 607–18. August 2006. doi:10.1016/j.molcel.2006.06.026. PMID 16916647. 
• "Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility". The Journal of Biological Chemistry 281 (45): 34677–86. November 2006. doi:10.1074/jbc.M606296200. PMID 16973615. 
• "Detection of novel mRNA splice variants of human ING4 tumor suppressor gene". Oncogene 26 (36): 5247–57. August 2007. doi:10.1038/sj.onc.1210335. PMID 17325660. 
• "Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation". Proceedings of the National Academy of Sciences of the United States of America 104 (22): 9517–22. May 2007. doi:10.1073/pnas.0703383104. PMID 17517644. Bibcode: 2007PNAS..104.9517Z. 

External links

• ING4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.