Biology:HOXB2

Short description: Protein-coding gene in humans

Generic protein structure example

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.

See also

• Homeobox

Further reading

• "A homeodomain protein binds to gamma-globin gene regulatory sequences". Proceedings of the National Academy of Sciences of the United States of America 88 (16): 7318–22. Aug 1991. doi:10.1073/pnas.88.16.7318. PMID 1871139. Bibcode: 1991PNAS...88.7318L. 
• "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity 40 (3): 191–7. Jun 1989. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724. 
• "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. Dec 1989. doi:10.1093/nar/17.24.10385. PMID 2574852. 
• "Organization of human class I homeobox genes". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652. 
• "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages". The EMBO Journal 7 (7): 2131–8. Jul 1988. doi:10.1002/j.1460-2075.1988.tb03052.x. PMID 2901346. 
• "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells". The Journal of Biological Chemistry 270 (9): 4544–50. Mar 1995. doi:10.1074/jbc.270.9.4544. PMID 7876223. 
• "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". The EMBO Journal 13 (14): 3339–47. Jul 1994. doi:10.1002/j.1460-2075.1994.tb06636.x. PMID 7913891. 
• "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". The Journal of Biological Chemistry 273 (18): 11092–9. May 1998. doi:10.1074/jbc.273.18.11092. PMID 9556594. 
• "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain". Neuron 22 (4): 677–91. Apr 1999. doi:10.1016/S0896-6273(00)80728-X. PMID 10230789. 
• "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation". DNA and Cell Biology 18 (11): 805–17. Nov 1999. doi:10.1089/104454999314809. PMID 10595394. 
• "HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema". The American Journal of Pathology 158 (3): 955–66. Mar 2001. doi:10.1016/S0002-9440(10)64042-4. PMID 11238043. 
• "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology 21 (21): 7509–22. Nov 2001. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930. 
• "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells". Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi 5 (1): 12–5. Feb 2002. PMID 11835749. 
• "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. Feb 2002. doi:10.1002/tera.10009. PMID 11857506. 
• "Regulation of Hoxb2 by APL-associated PLZF protein". Oncogene 22 (24): 3685–97. Jun 2003. doi:10.1038/sj.onc.1206328. PMID 12802276. 
• "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia". Clinical Cancer Research 11 (9): 3587–96. May 2005. doi:10.1158/1078-0432.CCR-04-1813. PMID 15867264. 

External links

• HOXB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.