Aldactone (spironolactone) is an anti-hypertensive and diuretic medication used to treat edema associated with excessive aldosterone, hypertension, primary hyperaldosteronism, hypokalemia, hirsutism, and cirrhosis. It works by competing with aldosterone for receptor sites, increasing sodium and water excretion while conserving potassium. Recommended dosages vary depending on the condition being treated, from 50-400 mg per day. Special precautions should be taken in patients with impaired renal function or who are taking other potassium-sparing drugs. Adverse effects can include gynecomastia, gastrointestinal issues, drowsiness, and menstrual irregularities
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online from Scribd
Aldactone (spironolactone) is an anti-hypertensive and diuretic medication used to treat edema associated with excessive aldosterone, hypertension, primary hyperaldosteronism, hypokalemia, hirsutism, and cirrhosis. It works by competing with aldosterone for receptor sites, increasing sodium and water excretion while conserving potassium. Recommended dosages vary depending on the condition being treated, from 50-400 mg per day. Special precautions should be taken in patients with impaired renal function or who are taking other potassium-sparing drugs. Adverse effects can include gynecomastia, gastrointestinal issues, drowsiness, and menstrual irregularities
Aldactone (spironolactone) is an anti-hypertensive and diuretic medication used to treat edema associated with excessive aldosterone, hypertension, primary hyperaldosteronism, hypokalemia, hirsutism, and cirrhosis. It works by competing with aldosterone for receptor sites, increasing sodium and water excretion while conserving potassium. Recommended dosages vary depending on the condition being treated, from 50-400 mg per day. Special precautions should be taken in patients with impaired renal function or who are taking other potassium-sparing drugs. Adverse effects can include gynecomastia, gastrointestinal issues, drowsiness, and menstrual irregularities
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online from Scribd
Aldactone (spironolactone) is an anti-hypertensive and diuretic medication used to treat edema associated with excessive aldosterone, hypertension, primary hyperaldosteronism, hypokalemia, hirsutism, and cirrhosis. It works by competing with aldosterone for receptor sites, increasing sodium and water excretion while conserving potassium. Recommended dosages vary depending on the condition being treated, from 50-400 mg per day. Special precautions should be taken in patients with impaired renal function or who are taking other potassium-sparing drugs. Adverse effects can include gynecomastia, gastrointestinal issues, drowsiness, and menstrual irregularities
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online from Scribd
Download as doc, pdf, or txt
You are on page 1of 2
Brand name: Aldactone
Generic name: Spironolactone
Indication: management of edema associated with excessive aldosterone excretion, hypertension, primary hyperaldosteronism, hypokalemia, treatment of hirsutism, cirrhosis of liver accompanied by edema or ascites Drug classification: anti-hypertensive agent, diuretic, potassium sparing Mechanism of action: competes with aldosterone for receptor sites in the distal renal tubules, increasing sodium chloride and water excretion while conserving potassium and hydrogen ions, may block the effect of aldosterone on arteriolar smooth muscle as well Dosage: essential hypertension Adult 50-100mg/day. Severe case: may be gradually increased at 2weekly intervals up to 200mg/day Edematous disorders Total daily dose may be given either in divided doses or as single daily dose. CHF adult 100mg/day. Maintenance: 25-200mg/day. Cirrhosis urinary Na+/K+ ratio > 1:100 mg/day, ratio <1:200-400mh/day. Nephritic syndrome 100-200mg/day. Edema in children initially 3mg/kg body wt daily in divided dose, reduced to 1-2mg/kg for maintenance therapy. Malignant hypertension adjunctive therapy, initially 100mg/day increased as necessary at 2weekly intervals to 400mg/day. Hypokalemia/hypomagnesaemia 25-100mg daily. Diagnosis and treatment of primary aldosteronism: long test:400mg/day for 3-4 wks. Short test 400 mg/day for 4 days. Special precaution: concomitant use with other K-retaining drugs pr K- supplements; impaired renal function; lactation; anaesthesia Pregnancy risk factor D Adverse reactions: gynecomastia; GI symptoms; drowsiness; lethargy; headache; mental condusion; ataxia; impotence; menstrual irregularities; post menopose bleedidng; rarely agranulocytosis; usticaria; fever; Contraindications: acute renal insufficiency, anuria, hyperkalemia. pregnancy Form: tab 25mg x 100s, 50mg x 100s; 100mg x 100s Nursing responsibilities: Educate patient to avoid hazardous activity such as driving until response to drug is known. Take with meals or milk; avoid excessive ingestion of food high in potassium or use of salt substitutes Diuretic effect may be delayed 2-3 days and maximum hypertensive may be delayed 2- 3weeks; monitor I and O ratios and daily weight, BP, serum electrolytes (K, Na) and renal function