호모 사피엔스 종의 단백질 코드 유전자
트롬보스폰딘 모티브 1을 가진 분해효소 및 금속단백질가수분해효소 는 ADAMTS1 [5] [6] 효소 이다.
기능. 이 유전자는 ADAMTS (트롬보스폰딘 모티브를 가진 분해 및 금속단백질가수분해효소 ) 단백질 패밀리의 구성원을 암호화합니다. 패밀리 구성원은 프로페타이드 영역, 메탈로프로테이나아제 도메인, 분해형 도메인 및 트롬보스폰딘 타입 1(TS) 모티브를 포함한 몇 가지 다른 단백질 모듈을 공유한다. 이 패밀리의 개별 멤버는 C-terminal TS 모티브의 수가 다르며, 일부 멤버는 고유한 C-terminal 도메인을 가지고 있습니다. 이 유전자에 의해 코드된 단백질은 2개의 분해 루프와 3개의 C-말단 TS 모티브를 포함하고 항혈관신생 활성을 가지고 있다. 이 유전자의 발현은 다양한 염증 과정뿐만 아니라 암 악세사리증 의 발병과 관련이 있을 수 있다. 이 유전자는 정상적인 성장, 번식력, 그리고 장기 형태와 [6]
상호 작용 ADAMTS1은 혈관내피성장인자 [7] A 와 상호작용하는 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000154734 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022893 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (September 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity" . J Biol Chem . 274 (33): 23349–57. doi :10.1074/jbc.274.33.23349 PMID 10438512 . ^ a b "Entrez Gene: ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1" .^ Luque A, Carpizo DR, Iruela-Arispe ML (June 2003). "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165" . J. Biol. Chem . 278 (26): 23656–65. doi :10.1074/jbc.M212964200 PMID 12716911 . 추가 정보 Tang BL, Hong W (1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats" . FEBS Lett . 445 (2–3): 223–5. doi :10.1016/S0014-5793(99)00119-2 PMID 10094461 . S2CID 37955930 . Hirohata S (2002). "[ADAMTS family--new extracellular matrix degrading enzyme]". Seikagaku . 73 (11): 1333–7. PMID 11831030 . Kuno K, Kanada N, Nakashima E, et al. (1997). "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene" . J. Biol. Chem . 272 (1): 556–62. doi :10.1074/jbc.272.1.556 PMID 8995297 . Kuno K, Matsushima K (1998). "ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region" . J. Biol. Chem . 273 (22): 13912–7. doi :10.1074/jbc.273.22.13912 PMID 9593739 . Kuno K, Terashima Y, Matsushima K (1999). "ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix" . J. Biol. Chem . 274 (26): 18821–6. doi :10.1074/jbc.274.26.18821 PMID 10373500 . Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (1): 65–73. doi :10.1093/dnares/7.1.65 PMID 10718198 . Glienke J, Schmitt AO, Pilarsky C, et al. (2000). "Differential gene expression by endothelial cells in distinct angiogenic states" . Eur. J. Biochem . 267 (9): 2820–30. doi :10.1046/j.1432-1327.2000.01325.x PMID 10785405 . Shindo T, Kurihara H, Kuno K, et al. (2000). "ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function" . J. Clin. Invest . 105 (10): 1345–52. doi :10.1172/JCI8635 . PMC 315464 PMID 10811842 . Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21" . Nature . 405 (6784): 311–9. Bibcode :2000Natur.405..311H . doi :10.1038/35012518 PMID 10830953 . Kuno K, Okada Y, Kawashima H, et al. (2000). "ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan" . FEBS Lett . 478 (3): 241–5. doi :10.1016/S0014-5793(00)01854-8 PMID 10930576 . S2CID 32699689 . Sandy JD, Westling J, Kenagy RD, et al. (2001). "Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4" . J. Biol. Chem . 276 (16): 13372–8. doi :10.1074/jbc.M009737200 PMID 11278559 . Wei P, Zhao YG, Zhuang L, et al. (2002). "Protein engineering and properties of human metalloproteinase and thrombospondin 1". Biochem. Biophys. Res. Commun . 293 (1): 478–88. doi :10.1016/S0006-291X(02)00255-3 . PMID 12054626 . Rodríguez-Manzaneque JC, Westling J, Thai SN, et al. (2002). "ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors". Biochem. Biophys. Res. Commun . 293 (1): 501–8. doi :10.1016/S0006-291X(02)00254-1 . PMID 12054629 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Luque A, Carpizo DR, Iruela-Arispe ML (2003). "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165" . J. Biol. Chem . 278 (26): 23656–65. doi :10.1074/jbc.M212964200 PMID 12716911 . Russell DL, Doyle KM, Ochsner SA, et al. (2004). "Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation" . J. Biol. Chem . 278 (43): 42330–9. doi :10.1074/jbc.M300519200 PMID 12907688 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 .
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