YWHAE

YWHAE
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	2BR9, 3UAL, 3UBW
식별자
별칭	YWHAE, 14-3-3E, HEL2, KCIP-1, MDCR, MDS, tyrosine 3-monoxygenase/tryptophan 5-monoxygenase 활성화 단백질 엡실론
외부 ID	OMIM: 605066 MGI: 894689 호몰로진: 100743 GeneCard: YWHAE
유전자 위치(인간)
쳇.	17번 염색체(인간)
끝	1400,190 bp
유전자 위치(마우스)
쳇.	11번 염색체(쥐)
끝	75,656,671 bp
RNA 표현 패턴
	표현된 상단
	상전두회; ; 전두엽 피질; ; 강리온의 명성; ; 말뭉치 담낭; ; 등측 전전두피질; ; 브로드만 9구역; ; 측두엽; ; 편도체; ; 입자핵; ; 본래의 해마;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	투과형 트랜스포터 바인딩; 단백질 영역별 결합; GO:0032403 단백질 함유 복합 결합; 히스톤 디 아세틸라제 바인딩; 칼륨 채널 조절기 활성; 인산단백질 결합; GO:0001948 단백질 결합; MHC 클래스 II 단백질 복합 결합; 단백질 이질화 활동; 효소 결합; 인광 잔류물 결합; 유비퀴틴 단백질 리가제 결합; 세포-세포 접착에 관련된 캐더린 결합; RNA 결합; 칼슘 통로 조절기 활동; 동일한 단백질 결합; 캐더린 제본; 비계단백질결합;
셀룰러 컴포넌트	세포질; 시토솔; 막으로 막다; 키네신 콤플렉스; 초점 접착; 흑색성의; 액손; 미토콘드리온; 세포외 외성체; 세포질 방광막; 핵의; 플라즈마 막; 시냅스; 성장 원뿔의 중심부; 글루타마테라믹 시냅스;
생물학적 과정	단백질 타겟팅; 단백질 비인산화에 대한 음의 조절; GO:0007243 세포내 신호 전달; 흑인의 발달을 증명하다.; 뉴런의 이동; 펩티딜-세린 탈인산화의 음성 조절; 하마 신호; 세포외 신호 경로에 관여하는 미토콘드리아 막에 단백질 삽입의 양성 조절; 유사 세포 주기의 G2/M 전환; 호르몬에 의한 심박수 조절; 칼륨 이온 투과형 트랜스포터 활성 조절; 대뇌피질 발달; 열에 대한 세포 반응 조절; 막 재분극 규제; 막 조직; GO:0022415 바이러스 처리; 심장 전도에 의한 심박수 조절; 심장 근육 세포 작용 전위 중 막 재분극; 해마 개발; 세포-세포 접착; 세포사멸과정에 관여하는 시스테인형 내분비효소 활성에 대한 부정적인 규제; MAPK 계단식 계단식; 유사 세포 주기의 G2/M 전환 규제; 핵에 대한 단백질 국산화; 열에 대한 세포 반응; 핵으로부터의 단백질 수출에 대한 양성 규제; 세포질 칼슘 이온 농도 조절; 담도 기저부 체외막 도킹; 시냅스 후막 신경전달물질 수용체 수준 조절; 칼슘 이온 투과성 전달체 활동에 대한 음의 조절; 혈장 막 전체에 걸친 칼슘 이온 수출의 음성 조절;
	출처:아미고 / 퀵고
직교체
	7531
	22627
	ENSG00000274474; ENSG00000108953
	ENSMUSG00000020849
	P62258
	P62259
	NM_006761
	NM_009536
	NP_006752
	NP_033562
	위키다타
인간 보기/편집	마우스 보기/편집

14-3-3 단백질 엡실론은 인간에게 YWHAE 유전자에 의해 암호화된 단백질이다.^[5]

함수

이 유전자 제품은 인산염 함유 단백질에 결합해 신호 전도를 중재하는 14-3-3 단백질군에 속한다.이 보존도가 높은 단백질군은 식물과 포유류 모두에서 발견되며, 이 단백질은 쥐의 직교와 100% 동일하다.CDC25 인산염, RAF1, IRS1 단백질과 상호작용하여 세포분열, 인슐린 민감도 조절 등 신호전달과 관련된 다양한 생화학적 활동에서 그 역할을 제시한다.그것은 또한 작은 세포 폐암의 병원성,^[6] 그리고 밀러-디커 증후군과 관련된 미세 변질에도 연루되었다.^[7]

상호작용

YWHAE는 다음과 상호 작용하는 것으로 나타났다.

참고 항목

14-3-3 단백질

참조

^ ^a ^b ^c ENSG00000108953 GRCh38: 앙상블 릴리스 89: ENSG00000274474, ENSG00000108953 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000020849 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Luk SC, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM (December 1997). "Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization". Cytogenet Cell Genet. 78 (2): 105–6. doi:10.1159/000134638. PMID 9371399.
^ "Entrez Gene: YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide".
^ Blazejewski SM, Bennison SA, Smith TH, Toyo-Oka K (2018). "Neurodevelopmental Genetic Diseases Associated With Microdeletions and Microduplications of Chromosome 17p13.3". Frontiers in Genetics. 9: 80. doi:10.3389/fgene.2018.00080. PMC 5876250. PMID 29628935.
^ ^a ^b Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. doi:10.1073/pnas.92.17.7892. PMC 41252. PMID 7644510.
^ Vincenz C, Dixit VM (August 1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. PMID 8702721.
^ Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. PMID 10713667.
^ Miska EA, Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T (August 2001). "Differential localization of HDAC4 orchestrates muscle differentiation". Nucleic Acids Res. 29 (16): 3439–47. doi:10.1093/nar/29.16.3439. PMC 55849. PMID 11504882.
^ Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.
^ Kagan A, Melman YF, Krumerman A, McDonald TV (April 2002). "14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity". EMBO J. 21 (8): 1889–98. doi:10.1093/emboj/21.8.1889. PMC 125975. PMID 11953308.
^ ^a ^b Craparo A, Freund R, Gustafson TA (April 1997). "14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner". J. Biol. Chem. 272 (17): 11663–9. doi:10.1074/jbc.272.17.11663. PMID 9111084.
^ Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR (February 1998). "14-3-3 proteins interact with specific MEK kinases". J. Biol. Chem. 273 (6): 3476–83. doi:10.1074/jbc.273.6.3476. PMID 9452471.
^ Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A (July 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nat. Genet. 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778. S2CID 10301633.
^ Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.
^ McGonigle S, Beall MJ, Feeney EL, Pearce EJ (February 2001). "Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors". FEBS Lett. 490 (1–2): 65–9. doi:10.1016/S0014-5793(01)02133-0. PMID 11172812. S2CID 84710903.

추가 읽기

Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780. S2CID 23655886.
Jones DH, Ley S, Aitken A (1995). "Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins". FEBS Lett. 368 (1): 55–8. doi:10.1016/0014-5793(95)00598-4. PMID 7615088. S2CID 7233378.
Conklin DS, Galaktionov K, Beach D (1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. doi:10.1073/pnas.92.17.7892. PMC 41252. PMID 7644510.
Jin DY, Lyu MS, Kozak CA, Jeang KT (1996). "Function of 14-3-3 proteins". Nature. 382 (6589): 308. doi:10.1038/382308a0. PMID 8684458. S2CID 7296682.
Vincenz C, Dixit VM (1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. PMID 8702721.
Chong SS, Tanigami A, Roschke AV, Ledbetter DH (1997). "14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region". Genome Res. 6 (8): 735–41. doi:10.1101/gr.6.8.735. PMID 8858348.
Craparo A, Freund R, Gustafson TA (1997). "14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner". J. Biol. Chem. 272 (17): 11663–9. doi:10.1074/jbc.272.17.11663. PMID 9111084.
Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J (1997). "Protein binding and signaling properties of RIN1 suggest a unique effector function". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 4954–9. doi:10.1073/pnas.94.10.4954. PMC 24612. PMID 9144171.
Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T (1997). "14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain". J. Biol. Chem. 272 (40): 25267–74. doi:10.1074/jbc.272.40.25267. PMID 9312143.
Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11". Mol. Endocrinol. 11 (12): 1858–67. doi:10.1210/me.11.12.1858. PMID 9369453.
Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR (1998). "14-3-3 proteins interact with specific MEK kinases". J. Biol. Chem. 273 (6): 3476–83. doi:10.1074/jbc.273.6.3476. PMID 9452471.
Ku NO, Liao J, Omary MB (1998). "Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins". EMBO J. 17 (7): 1892–906. doi:10.1093/emboj/17.7.1892. PMC 1170536. PMID 9524113.
Luk SC, Ngai SM, Tsui SK, Fung KP, Lee CY, Waye MM (1999). "In vivo and in vitro association of 14-3-3 epsilon isoform with calmodulin: implication for signal transduction and cell proliferation". J. Cell. Biochem. 73 (1): 31–5. doi:10.1002/(SICI)1097-4644(19990401)73:1<31::AID-JCB4>3.0.CO;2-X. PMID 10088721.
Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and functional homology with 14-3-3 proteins". J. Neurosci. 19 (14): 5782–91. doi:10.1523/JNEUROSCI.19-14-05782.1999. PMC 6783081. PMID 10407019.
Finlin BS, Andres DA (1999). "Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins". Arch. Biochem. Biophys. 368 (2): 401–12. doi:10.1006/abbi.1999.1316. PMID 10441394.
Dorner C, Ullrich A, Häring HU, Lammers R (1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.
Aoki H, Hayashi J, Moriyama M, Arakawa Y, Hino O (2000). "Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and Activates the Kinase Raf-1". J. Virol. 74 (4): 1736–41. doi:10.1128/JVI.74.4.1736-1741.2000. PMC 111649. PMID 10644344.

[refGRCh38Ensembl-1] ENSG00000108953 GRCh38: 앙상블 릴리스 89: ENSG00000274474, ENSG00000108953 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000020849 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9371399-5] Luk SC, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM (December 1997). "Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization". Cytogenet Cell Genet. 78 (2): 105–6. doi:10.1159/000134638. PMID 9371399.

[6] "Entrez Gene: YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide".

[pmid29628935-7] Blazejewski SM, Bennison SA, Smith TH, Toyo-Oka K (2018). "Neurodevelopmental Genetic Diseases Associated With Microdeletions and Microduplications of Chromosome 17p13.3". Frontiers in Genetics. 9: 80. doi:10.3389/fgene.2018.00080. PMC 5876250. PMID 29628935.

[pmid7644510-8] Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. doi:10.1073/pnas.92.17.7892. PMC 41252. PMID 7644510.

[pmid8702721-9] Vincenz C, Dixit VM (August 1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. PMID 8702721.

[pmid10713667-10] Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. PMID 10713667.

[pmid11504882-11] Miska EA, Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T (August 2001). "Differential localization of HDAC4 orchestrates muscle differentiation". Nucleic Acids Res. 29 (16): 3439–47. doi:10.1093/nar/29.16.3439. PMC 55849. PMID 11504882.

[pmid10869435-12] Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.

[pmid11953308-13] Kagan A, Melman YF, Krumerman A, McDonald TV (April 2002). "14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity". EMBO J. 21 (8): 1889–98. doi:10.1093/emboj/21.8.1889. PMC 125975. PMID 11953308.

[pmid9111084-14] Craparo A, Freund R, Gustafson TA (April 1997). "14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner". J. Biol. Chem. 272 (17): 11663–9. doi:10.1074/jbc.272.17.11663. PMID 9111084.

[pmid9452471-15] Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR (February 1998). "14-3-3 proteins interact with specific MEK kinases". J. Biol. Chem. 273 (6): 3476–83. doi:10.1074/jbc.273.6.3476. PMID 9452471.

[pmid12796778-16] Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A (July 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nat. Genet. 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778. S2CID 10301633.

[pmid11278287-17] Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.

[pmid11172812-18] McGonigle S, Beall MJ, Feeney EL, Pearce EJ (February 2001). "Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors". FEBS Lett. 490 (1–2): 65–9. doi:10.1016/S0014-5793(01)02133-0. PMID 11172812. S2CID 84710903.

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Search

YWHAE

네임스페이스

더

목차

함수

상호작용

참고 항목

참조

추가 읽기