Pathophsyiology of AGE

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V.

Pathophysiology of the Disease


Non-Modifiable Risk factors
Gender (Male)
Age (19 y/o)

Modifiable Risk factors


Lifestyle/Diet
(Ingestion of contaminated food and water)

Etiology: Salmonella, Shigella, Staphylococcus, Campylobacter jejuni,


Clostridium, Escherichia coli, Yersinia,Norovirus, adenovirus
Ingestion of Pathogens
Entry and growth of infection in the
intestines

Nausea &
vomiting

Endotoxins are released

Direct invasion of the bowel wall

Fluid and electrolytes


imbalance

Stimulation and destruction of mucosal


lining of the bowel wall

Secretion of fluid &


electrolytes in the
intestinal lumen

Digestive and absorptive


malfunction
Increased peristaltic
movement

Dehydration
Excessive
gas formation

GI Distention

Increased secretion of Cl &


HCO3 ions in the bowel

Inhibition of Na reabsorption
Diarrhea

Dry lips,
dry mouth,
fatigue

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