IFNAR2
IFNAR2| IFNAR2 | |||||||||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||||||||
| 에일리어스 | IFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNAB, IMD45, 간섭체 알파 및 베타수용체 서브유닛2 | ||||||||||||||||||||||||||||||
| 외부 ID | OMIM: 602376 MGI: 1098243 HomoloGene: 49242 GenCards: IFNAR2 | ||||||||||||||||||||||||||||||
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인터페론-알파/베타 수용체 베타사슬은 IFNAR2 [5]유전자에 의해 인간에서 암호화되는 단백질이다.
기능.
이 유전자에 의해 암호화된 단백질은 간섭자 알파와 베타 수용체의 두 개의 사슬 중 하나를 형성하는 I형 막 단백질입니다.수용체의 결합 및 활성화는 야누스 단백질 키나제를 자극하여 STAT1 및 STAT2를 포함한 여러 단백질을 인산화한다.이 [6]유전자에 대해 적어도 2개의 다른 아이소폼을 코드하는 복수의 전사 변이가 발견되었다.
상호 작용
IFNAR2는 다음과 상호작용하는 것으로 나타났습니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000159110 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022971 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Novick D, Cohen B, Rubinstein M (June 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell. 77 (3): 391–400. doi:10.1016/0092-8674(94)90154-6. PMID 8181059. S2CID 140206806.
- ^ "Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2".
- ^ a b Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. 276 (25): 22948–53. doi:10.1074/jbc.M100087200. PMID 11301323.
- ^ Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (November 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. doi:10.4049/jimmunol.165.9.5127. PMID 11046044.
- ^ Piehler J, Schreiber G (May 1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID 10339405.
- ^ a b Li X, Leung S, Kerr IM, Stark GR (April 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
- ^ Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (March 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. 277 (12): 9713–21. doi:10.1074/jbc.M111161200. PMID 11786546.
추가 정보
- Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A (2005). "Alpha-interferon and its effects on signal transduction pathways". J. Cell. Physiol. 202 (2): 323–35. doi:10.1002/jcp.20137. PMID 15389589. S2CID 4833543.
- Raz R, Cheung K, Ling L, Levy DE (1995). "Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness". Somat. Cell Mol. Genet. 21 (2): 139–45. doi:10.1007/BF02255789. PMID 7570186. S2CID 972314.
- Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE (1995). "Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster". EMBO J. 14 (20): 5100–8. doi:10.1002/j.1460-2075.1995.tb00192.x. PMC 394613. PMID 7588638.
- Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995). "Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling". J. Biol. Chem. 270 (37): 21606–11. doi:10.1074/jbc.270.37.21606. PMID 7665574.
- Novick D, Cohen B, Tal N, Rubinstein M (1995). "Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor". J. Leukoc. Biol. 57 (5): 712–8. doi:10.1002/jlb.57.5.712. PMID 7759950.
- Platanias LC, Uddin S, Domanski P, Colamonici OR (1996). "Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor". J. Biol. Chem. 271 (39): 23630–3. doi:10.1074/jbc.271.39.23630. PMID 8798579.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Croze E, Russell-Harde D, Wagner TC, Pu H, Pfeffer LM, Perez HD (1996). "The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein". J. Biol. Chem. 271 (52): 33165–8. doi:10.1074/jbc.271.52.33165. PMID 8969169.
- Li X, Leung S, Kerr IM, Stark GR (1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
- Piehler J, Schreiber G (1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID 10339405.
- Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K (1999). "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2". J. Immunol. 163 (2): 766–73. PMID 10395669.
- Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
- Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. doi:10.4049/jimmunol.165.9.5127. PMID 11046044.
- Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. 276 (25): 22948–53. doi:10.1074/jbc.M100087200. PMID 11301323.
- Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. 277 (12): 9713–21. doi:10.1074/jbc.M111161200. PMID 11786546.
- Chill JH, Nivasch R, Levy R, Albeck S, Schreiber G, Anglister J (2002). "The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening". Biochemistry. 41 (11): 3575–85. doi:10.1021/bi011778f. PMID 11888273.
- Velichko S, Wagner TC, Turkson J, Jove R, Croze E (2002). "STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues". J. Biol. Chem. 277 (38): 35635–41. doi:10.1074/jbc.M204578200. PMID 12105218.
- Usacheva A, Kotenko S, Witte MM, Colamonici OR (2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. 169 (3): 1302–8. doi:10.4049/jimmunol.169.3.1302. PMID 12133952.
- Gauzzi MC, Canini I, Eid P, Belardelli F, Gessani S (2002). "Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells". J. Immunol. 169 (6): 3038–45. doi:10.4049/jimmunol.169.6.3038. PMID 12218119.
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