Silverthorn 5th-16 Blood PDF
Silverthorn 5th-16 Blood PDF
Silverthorn 5th-16 Blood PDF
16
Macbeth,V,i,42,byWilliamShakespeare
BACKGROUNDBASICS
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RUNNINGPROBLEM
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*FIGURE16-1.
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CONCEPTCHECK
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C
I
R
C
U
L
A
T
I
O
N
B
O
N
E
M
A
R
R
O
W
*FIGURE16-2
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*FIGURE16-3
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CONCEPTCHECK
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RUNNINGPROBLEM
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FOCUSON...BONEMARROW
*FIGURE16-4
554
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RedBloodCells555
3
2
1
4
5
*FIGURE16-6
(a)(b)
(c)
*FIGURE16-5
(a)(b)(c)
CLINICALFOCUS
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8
7
6
CONCEPTCHECK
*FIGURE16-7
8
1
2
3
5
6
7
4
88
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RedBloodCells557
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*FIGURE16-8Sickledredbloodcells
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CONCEPTCHECK
PLATELETSANDCOAGULATION
RUNNINGPROBLEM
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Hemostasis
3
2 1
*FIGURE16-10
+
1
2
3
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Impide la adhesion
de las plaquetas
Luz del vaso
sanguineo
Endotelio
indemne
Celulas
Musculares
Lisas
Capa
de colageno
subendotelial
Colageno expuesto
en la pared lesionada
del vaso sanguineo
Liquido
extracelular
1
1
2
3
4
2
3
4
Libera
prostaciclina
y oxido nitrico
El colageno expuesto se une
con las plaquetas y las activa
Se libera factores
plaquetarios
Los factores atraen mas
plaquetas
Las plaquetas se agregan y
forman un tapon plaquetario
*FIGURE16-11
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RUNNINGPROBLEM
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*
*
+ +
VIA INTRINSECA
VIA COMUN
VIA EXTRINSECA
Red de Fibrina
Trombina
Fibrina
IX Activo
X Activo
XIII Activo
Factor tisular
(III) y
VII activo
Colageno u otros factores
activadores
La lesion expone
factor tisular (III)
XII Activo
XI Activo
XII
VIII
VII
IX
XI
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Fibrinogeno
Protrombina
Ca
2+
,
V, PL
I I I X
retroalimentacion positiva
retroalimentacion positiva
Fosfolipidos (PL)
X
* FIGURE 16-12 The coagula-
tion cascade. Inactive plasma pro-teins
are converted into active en-zymes in
each step of the pathway.
*FIGURE16-13
Trombina Plasminogeno
Polimero
de Fibrina
Plasmina
tPA
Fragmentos
de fibrina
Coagulacion Fibrinolisis
Fibrinogeno
Coagulo
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CONCEPTCHECK
*FIGURE16-14
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EMERGINGCONCEPTS
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RUNNINGPROBLEMCONCLUSION
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THEPHYSIOLOGYPLACE
ThePhysiologyPlace
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Answers567
16
REVIEWINGCONCEPTS
QUANTITATIVEPROBLEMS
PROBLEMSOLVING
ANSWERS
SS
SS
S
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