커밀-4CN-비나카

CUMYL-4CN-BINACA
커밀-4CN-비나카
CUMYL-4CN-BINACA.svg
법적현황
법적현황
식별자
  • 1-(4-Cyanobutyl)-N-(2-페닐프로판-2-yl)-1H-indazole-3-카복사미드
CAS 번호
켐스파이더
유니
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C22H24N4O
어금질량360.461 g·190−1
3D 모델(JSmol)
  • O=C(NC(C)C1=CC=CC=C1)C2=NN(CCCC#N)C3=C2C=CC=C3.C3
  • InChI=1S/C22H24N4O/c1-22(2,17-11-5-3-6-12-17)24-21(27)20-18-13-7-8-14-19(18)26(25-20)16-10-4-9-15-23/h3,5-8,11-14H,4,9-10,16H2,1-2H3,(H,24,27)
  • 키:JGTSOWISVAHG-UHFFFAOYSA-N

CUMIL-4CN-BINACA(CUMIL-CYBINACA 또는 SGT-78로도 알려져 있음)는 인다졸-3 카르복사미드 기반 합성 카나비노이드로, 디자이너 약품으로 온라인에서 판매되어 왔다.[1][2][3][4][5][6] 캐나비노이드 수용체 CB와1 CB에2 대한 강력한 작용제로 체외 EC50 값이 각각 0.58nM, 6.12nM이다.[7] 생쥐의 경우 CB1 수용체를 통해 CUMIL-4CN-BINACA가 저열 및 친경화 효과를 발생시키고 있으며,[7] 일화 보고에 따르면 인간에게 약 0.1mg의 활성 선량을 가지고 있다.[8]

CUMIL-4CN-BINACA는 대사 작용을 통해 청산가리를 생산하고 있어 간 독성에 대한 우려가 제기된다.[6] 그것의 사용과 관련하여 온열, 횡문근융해증, 신장 기능 부전의 보고된 사례가 있다.[9]

참고 항목

참조

  1. ^ "4-cyano CUMYL-BUTINACA". Cayman Chemical.
  2. ^ Yeter O (November 2017). "Identification of the Synthetic Cannabinoid 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide (CUMYL-4CN-BINACA) in Plant Material and Quantification in Post-Mortem Blood Samples". Journal of Analytical Toxicology. 41 (9): 720–728. doi:10.1002/dta.2248. PMID 28977413.
  3. ^ Staeheli SN, Poetzsch M, Veloso VP, Bovens M, Bissig C, Steuer AE, Kraemer T (January 2018). "In vitro metabolism of the synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and CUMYL-4CN-B7AICA". Drug Testing and Analysis. 10 (1): 148–157. doi:10.1002/dta.2298. PMID 28885775.
  4. ^ Bovens M, Bissig C, Staeheli SN, Poetzsch M, Pfeiffer B, Kraemer T (December 2017). "Structural characterization of the new synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and CUMYL-4CN-B7AICA". Forensic Science International. 281: 98–105. doi:10.1016/j.forsciint.2017.10.020. PMID 29125990.
  5. ^ Ölmez, Nevin Arıkan; Kapucu, Hicran; Altun, Neslihan Çallı; Eren, Bülent (January 2018). "Identification of the synthetic cannabinoid N-(2-phenyl-propan-2-yl)-1-(4-cyanobutyl)-1H-indazole-3-carboxamide (CUMYL-4CN-BINACA) in a herbal mixture product". Forensic Toxicology. 36 (1): 192–199. doi:10.1007/s11419-017-0372-y. ISSN 1860-8965. S2CID 28058750.
  6. ^ a b Åstrand, Anna; Vikingsson, Svante; Lindstedt, Daniel; Thelander, Gunilla; Gréen, Henrik; Kronstrand, Robert; Wohlfarth, Ariane (2018). "Metabolism study for CUMYL-4CN-BINACA in human hepatocytes and authentic urine specimens: Free cyanide is formed during the main metabolic pathway". Drug Testing and Analysis. 10 (8): 1270–1279. doi:10.1002/dta.2373. ISSN 1942-7611. PMID 29577658.
  7. ^ a b Kevin, Richard; Anderson, Lyndsey; McGregor, Iain; Boyd, Rochelle; Manning, Jamie; Glass, Michelle; Connor, Mark; Banister, Samuel (2019). "CUMYL-4CN-BINACA is an efficacious and potent pro-convulsant synthetic cannabinoid receptor agonist". Frontiers in Pharmacology. 10: 595. doi:10.3389/fphar.2019.00595. PMC 6549035. PMID 31191320.
  8. ^ "EMCDDA–Europol Joint Report on a new psychoactive substance: 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide (CUMYL-4CN-BINACA)". www.emcdda.europa.eu.
  9. ^ El Zahran, Tharwat (August 2018). "A novel synthetic cannabinoid (Cumyl-4-cyano-BINACA) resulting in hyperthermia, rhabdomyolysis, and renal failure in a 29-year-old patient: it's not meningitis". Clinical Toxicology. 57 (6): 421–422. doi:10.1080/15563650.2018.1534241. PMID 30442067. S2CID 53566116.
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이 카나비노이드 관련 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.