C5a 아나필라톡신 화학수용체 C5a2 는 C5L2, G단백질결합수용체 77 로 알려져 있으며, 인간에서 C5AR2 유전자 에 의해 인코딩 되는 단백질이다.[5] [6]
함수 아나필라톡신스 C3a, C4a, C5a는 숙주 방어에 참여하는 보완 캐스케이드 동안 생성된 양이온 파편이다.부적절한 보완 활성화 의 경우 아나필라톡신(anaphylatoxins )은 자가면역성 및 패혈증 에 관여할 수 있다. C5a2는 다결정핵 중성미자 에 C5a 수용체 (C5a1, C5aR, C5R1, CD88)와 공존하며 C5a1 활동을 변조할 수 있다.[6] [7]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000134830 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000074361 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res . 86 (1–2): 13–22. doi :10.1016/S0169-328X(00)00242-4 . PMID 11165367 . ^ a b "HGNC:4527" . Retrieved 2019-08-30 .^ Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C (December 2005). "An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2" . J. Biol. Chem . 280 (48): 39677–80. doi :10.1074/jbc.C500287200 PMID 16204243 .
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