모페길린

Mofegiline
모페길린
Mofegiline.svg
임상자료
기타 이름MDL-72,974a
경로:
행정		구강[1]
ATC 코드
  • 없음
법적현황
법적현황
  • 개발이 종료됨
약동학 데이터
제거 반감기1~3시간[1]
배설오줌[2]
식별자
  • (2E)-2-(fluoromethylidene)-4-(4-fluorophenyl)부탄-1-아민
CAS 번호
펍켐 CID
켐스파이더
유니
화학 및 물리적 데이터
공식C11H13F2N
어금질량197.17 g·190−1
3D 모델(JSmol)
  • Fc1ccc(cc1)CC(=[C@H]F)씨엔
  • InChi=1S/C11H13F2N/c12-7-10(8-14)2-1-9-3-5-11(13)6-4-9/h3-7H,1-2,8,14H2/b10-7+
  • 키:VXLBSYHACKDUSU-JXMROGBWSA-N

모페길린(MDL-72,974)은 파킨슨병 및 알츠하이머병 치료제로 조사 중이었으나 [3][4][5][6]시판되지 않은 모노아민 산화효소 B(MAO-B)와 세미바르바지드민 민감 아민 산화효소(SAO)의 선택적, 불가역적 억제제다.[7]

참고 항목

참조

  1. ^ a b Stoltz M, Reynolds D, Elkins L, Salazar D, Weir S (September 1995). "Pharmacokinetics and pharmacodynamics of the monoamine oxidase B inhibitor mofegiline assessed during a phase I dose tolerance trial". Clinical Pharmacology and Therapeutics. 58 (3): 342–53. doi:10.1016/0009-9236(95)90252-X. PMID 7554709.
  2. ^ Dulery BD, Schoun J, Zreika M, et al. (March 1993). "Pharmacokinetics of and monoamine oxidase B inhibition by (E)-4-fluoro-beta-fluoromethylene benzene butanamine in man". Arzneimittel-Forschung. 43 (3): 297–302. PMID 8489556.
  3. ^ Palfreyman MG, McDonald IA, Bey P, Schechter PJ, Sjoerdsma A (1988). "Design and early clinical evaluation of selective inhibitors of monoamine oxidase". Progress in Neuro-psychopharmacology & Biological Psychiatry. 12 (6): 967–87. doi:10.1016/0278-5846(88)90092-9. PMID 3266532. S2CID 32734728.
  4. ^ Zreika M, Fozard JR, Dudley MW, Bey P, McDonald IA, Palfreyman MG (1989). "MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease". Journal of Neural Transmission. Parkinson's Disease and Dementia Section. 1 (4): 243–54. doi:10.1007/bf02263478. PMID 2597310. S2CID 26335432.
  5. ^ Palfreyman MG, McDonald IA, Bey P, Danzin C, Zreika M, Cremer G (1994). "Haloallylamine inhibitors of MAO and SSAO and their therapeutic potential". Journal of Neural Transmission. Supplementum. 41: 407–14. doi:10.1007/978-3-7091-9324-2_54. ISBN 978-3-211-82521-1. PMID 7931257.
  6. ^ Thiffault C, Quirion R, Poirier J (March 1998). "Effect of the MAO-B inhibitor, MDL72974, on superoxide dismutase activity and lipid peroxidation levels in the mouse brain". Synapse. 28 (3): 208–11. doi:10.1002/(SICI)1098-2396(199803)28:3<208::AID-SYN3>3.0.CO;2-E. PMID 9488505.
  7. ^ Ganellin, C. R.; Triggle, D. J.; Macdonald, F. (1997). Dictionary of pharmacological agents. CRC Press. p. 1370. ISBN 978-0-412-46630-4. Retrieved 25 November 2011.