A-84,543

A-84,543
A-84,543
A-84,543.svg
식별자
  • 3-{[(2S)-1-메틸-2-피롤리디닐]메톡시}피리딘
CAS 번호
  • 161416-43-9 ☒N
펍켐 CID
켐스파이더
켐벨
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C11H16N2O
어금질량192.257 g·190−1
3D 모델(JSmol)
  • CN1CC[C@H]1COc2cccnc2
  • InChi=1S/C11H16N2O/c1-13-7-3-4-10(13)9-14-11-5-2-6-12-8-11/h2,5-6,8,10H,3-4,7,9H2,1H3/t10-/m0/s1 ☒N
  • 키:MVLJPWPLDPHX-JTQLQIEISA-N ☒N
☒NcheckY (이게 뭐야?) (iii)

A-84543애보트가 개발한 약물로, α4β2 서브타입의 선택성이 높은 신경니코틴 아세틸콜린 수용체에서 작용제 역할을 한다. 이 수용체 아형의 구조와 기능에 대한 과학적 연구에 널리 사용되며, 관련 파생상품의 대가족 발전의 선도적 화합물이 되어 왔다.[1][2][3][4]

참조

  1. ^ Abreo MA, Lin NH, Garvey DS, Gunn DE, Hettinger AM, Wasicak JT, et al. (February 1996). "Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors". Journal of Medicinal Chemistry. 39 (4): 817–25. doi:10.1021/jm9506884. PMID 8632405.
  2. ^ Lin NH, Gunn DE, Li Y, He Y, Bai H, Ryther KB, et al. (February 1998). "Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist". Bioorganic & Medicinal Chemistry Letters. 8 (3): 249–54. doi:10.1016/S0960-894X(98)00019-5. PMID 9871663.
  3. ^ Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, et al. (March 2005). "Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits". Journal of Medicinal Chemistry. 48 (6): 1721–4. doi:10.1021/jm0492406. PMID 15771418.
  4. ^ Carreras J, Avenoza A, Busto JH, Peregrina JM (April 2007). "Synthesis of azabicyclo[2.2.n]alkane systems as analogues of 3-[1-methyl-2-(S)-pyrrolidinyl- methoxy]pyridine (A-84543)". The Journal of Organic Chemistry. 72 (8): 3112–5. doi:10.1021/jo0700732. PMID 17371077.