CX3CR1
CX3CR1
프랙탈카인 수용체 또는 G-단백 결합 수용체 13(GPR13)이라고도 알려진 CX3C 케모킨 수용체 1(CX3CR1)은 인간에서 CX3CR1 유전자에 의해 암호화된 단백질이다.[5][6]이름에서 알 수 있듯이 이 수용체는 케모킨 CX3CL1(신경탁틴 또는 프랙탈킨이라고도 한다)을 결합한다.
함수
프랙탈카인 리간드 CX3CL1은 백혈구의 접착과 이동에 관여하는 투과성 단백질과 케모카인이다.CX3CR1 유전자에 의해 인코딩된 단백질은 프랙탈카인 리간드의 수용체다.[7]
이 수용체의 표현은 림프구와 관련이 있는 것으로 보인다.[8]CX3CR1도 단세포에 의해 표현되며 단세포의 생존에 큰 역할을 한다.[9]
프랙탈카인 신호는 또한 최근 중추신경계의 미세글리아를 그들의 시냅스 목표물로 이동시키는 데 발달적인 역할을 하는 것으로 밝혀졌는데, 그 곳에서 혈소판과 시냅스 교양이 일어난다.CX3CR1 녹아웃 생쥐는 야생 생쥐보다 해마 뉴런에 시냅스가 더 많았다.[10]
임상적 유의성
CX3CR1은 또한 HIV-1의 핵심 수용체로서, 이 유전자의 일부 변화는 HIV-1 감염에 대한 민감도를 증가시키고 에이즈로 빠르게 진전시킨다.[7]
CX3CR1 변형은 근위축성 측경화증 환자의 생존 시간과 진행률을 수정하기 위해 설명되었다.[11]
CX3CR1의 돌연변이는 고관절 이형화와 관련이 있다.[12]동형체 CX3CR1-M280 돌연변이는 인간의 단세포 생존을 저해하고 인간 전신 칸디아의 결과를 악화시킨다.[13]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000168329 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000052336 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Combadiere C, Ahuja SK, Murphy PM (August 1995). "Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene". DNA and Cell Biology. 14 (8): 673–80. doi:10.1089/dna.1995.14.673. PMID 7646814.
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- ^ a b "Entrez Gene: chemokine (C-X3-C motif) receptor 1".
- ^ Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall TJ, Yoshie O (November 1997). "Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion". Cell. 91 (4): 521–30. doi:10.1016/S0092-8674(00)80438-9. PMID 9390561. S2CID 17281691.
- ^ Landsman L, Bar-On L, Zernecke A, Kim KW, Krauthgamer R, Shagdarsuren E, Lira SA, Weissman IL, Weber C, Jung S (January 2009). "CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival". Blood. 113 (4): 963–72. doi:10.1182/blood-2008-07-170787. PMID 18971423.
- ^ Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, Giustetto M, Ferreira TA, Guiducci E, Dumas L, Ragozzino D, Gross CT (September 2011). "Synaptic pruning by microglia is necessary for normal brain development". Science. 333 (6048): 1456–8. Bibcode:2011Sci...333.1456P. doi:10.1126/science.1202529. PMID 21778362. S2CID 12883061.
- ^ Lopez-Lopez A, Gamez J, Syriani E, Morales M, Salvado M, Rodríguez MJ, Mahy N, Vidal-Taboada JM (7 May 2014). "CX3CR1 is a modifying gene of survival and progression in amyotrophic lateral sclerosis". PLOS ONE. 9 (5): e96528. Bibcode:2014PLoSO...996528L. doi:10.1371/journal.pone.0096528. PMC 4013026. PMID 24806473.
- ^ Feldman GJ, Parvizi J, Sawan H, Erickson JA, Peters CL (September 2014). "Linkage mapping and whole exome sequencing identify a shared variant in CX3CR1 in a large multi-generation family". The Journal of Arthroplasty. 29 (9 Suppl): 238–41. doi:10.1016/j.arth.2014.05.014. PMID 24998320.
- ^ Collar AL, Swamydas M, O'Hayre M, Sajib MS, Hoffman KW, Singh SP, et al. (February 2018). "The homozygous CX3CR1-M280 mutation impairs human monocyte survival". JCI Insight. 3 (3). doi:10.1172/jci.insight.95417. PMC 5821174. PMID 29415879.
추가 읽기
- Robertson MJ (February 2002). "Role of chemokines in the biology of natural killer cells". Journal of Leukocyte Biology. 71 (2): 173–83. PMID 11818437.
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- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Mizoue LS, Bazan JF, Johnson EC, Handel TM (February 1999). "Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1". Biochemistry. 38 (5): 1402–14. doi:10.1021/bi9820614. PMID 9931005.
- Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome". Cytogenetics and Cell Genetics. 87 (3–4): 265–8. doi:10.1159/000015443. PMID 10702689. S2CID 1178132.
- Faure S, Meyer L, Costagliola D, Vaneensberghe C, Genin E, Autran B, Delfraissy JF, McDermott DH, Murphy PM, Debré P, Théodorou I, Combadière C (March 2000). "Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1". Science. 287 (5461): 2274–7. Bibcode:2000Sci...287.2274F. doi:10.1126/science.287.5461.2274. PMID 10731151.
- Yoneda O, Imai T, Goda S, Inoue H, Yamauchi A, Okazaki T, Imai H, Yoshie O, Bloom ET, Domae N, Umehara H (April 2000). "Fractalkine-mediated endothelial cell injury by NK cells". Journal of Immunology. 164 (8): 4055–62. doi:10.4049/jimmunol.164.8.4055. PMID 10754298.
- Meucci O, Fatatis A, Simen AA, Miller RJ (July 2000). "Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival". Proceedings of the National Academy of Sciences of the United States of America. 97 (14): 8075–80. Bibcode:2000PNAS...97.8075M. doi:10.1073/pnas.090017497. PMC 16672. PMID 10869418.
- Papadopoulos EJ, Fitzhugh DJ, Tkaczyk C, Gilfillan AM, Sassetti C, Metcalfe DD, Hwang ST (August 2000). "Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin". European Journal of Immunology. 30 (8): 2355–61. doi:10.1002/1521-4141(2000)30:8<2355::AID-IMMU2355>3.0.CO;2-#. PMID 10940926.
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- Foussat A, Bouchet-Delbos L, Berrebi D, Durand-Gasselin I, Coulomb-L'Hermine A, Krzysiek R, Galanaud P, Levy Y, Emilie D (September 2001). "Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients". Blood. 98 (6): 1678–86. doi:10.1182/blood.V98.6.1678. PMID 11535497.
- Dichmann S, Herouy Y, Purlis D, Rheinen H, Gebicke-Härter P, Norgauer J (November 2001). "Fractalkine induces chemotaxis and actin polymerization in human dendritic cells". Inflammation Research. 50 (11): 529–33. doi:10.1007/PL00000230. PMID 11766992. S2CID 26550147.
- Brand S, Sakaguchi T, Gu X, Colgan SP, Reinecker HC (January 2002). "Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells". Gastroenterology. 122 (1): 166–77. doi:10.1053/gast.2002.30329. PMID 11781291.
- Utaipat U, Duerr A, Rudolph DL, Yang C, Butera ST, Lupo D, Pisell T, Tangmunkongvorakul A, Kamtorn N, Nantachit N, Nagachinta T, Suriyanon V, Robison V, Nelson KE, Sittisombut N, Lal RB (January 2002). "Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives". AIDS Research and Human Retroviruses. 18 (1): 1–11. doi:10.1089/088922202753394664. PMID 11804551.
- Fong AM, Alam SM, Imai T, Haribabu B, Patel DD (May 2002). "CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion". The Journal of Biological Chemistry. 277 (22): 19418–23. doi:10.1074/jbc.M201396200. PMID 11909868.
외부 링크
- CX3CR1+단백질,+인간, 미국 국립 의학 도서관의 의학 과목 제목(MSH)
- "Chemokine Receptors: CX3CR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- UCSC 게놈 브라우저의 인간 CX3CR1 유전체 위치 및 CX3CR1 유전자 세부 정보 페이지.
이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.
