칼슘 활성 칼륨 채널 서브유닛 베타-1 은 인간에서 KCNMB1 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
함수 MaxiK 채널은 부드러운 근육톤과 뉴런의 흥분성을 제어하는 데 기본이 되는 큰 전도성, 전압 및 칼슘에 민감한 칼륨 채널이다. MaxiK 채널은 2개의 서브유닛 즉, 모공형 알파 서브유닛과 이 유전자의 산물인 조절 베타 서브유닛에 의해 형성될 수 있다. 세포내 칼슘은 알파와 베타 서브유닛 사이의 물리적 연관성을 조절한다.[7] 베타 서브유닛(베타 1-4)은 표현에 있어 매우 특이하며, 베타-1은 주로 혈관 매끄러운 근육에 존재한다. 내피세포는 베타-1 서브유닛을 표현하는 것으로 알려져 있지 않다. 베타-1은 또한 비뇨기 방광과 뇌의 일부 영역에서도 발현되는 것으로 알려져 있다. BK 채널과 베타-1 서브 유닛을 연결하면 채널의 겉보기 Ca2+ 감도가 증가하며 전압 의존도가 감소한다.[8]
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Bibcode :2014PLoSO...9j9306K . doi :10.1371/journal.pone.0109306 PMC 4183656 PMID 25275635 . 이 기사는 공공영역 에 있는 미국 국립 의학 도서관 의 텍스트를 통합하고 있다.
