미토겐 활성 단백질 키나제 11 은 인간에서 MAPK11 유전자 에 의해 암호화된 효소 다.[5] [6]
함수 이 유전자에 의해 인코딩된 단백질은 MAP 키나제 계열의 일원이다. MAP 키나제스는 복수의 생화학적 신호의 통합점 역할을 하며 증식 , 분화 , 전사 규제 , 개발 등 매우 다양한 세포 과정에 관여한다. 이 키나제는 p38 MAP 키나제 와 가장 밀접한 관계가 있는데, 두 가지 모두 염증 시토카인과 환경 스트레스에 의해 활성화될 수 있다. 이 키나제는 MKKs (MAP kinase kinases , MKKs)에 의한 인산화를 통해 활성화되며, MKK6에 의해 활성화된다. 전사 계수 ATF2/CREB2 는 이 키나아제의 기질로 밝혀졌다.[6]
상호작용 MAPK11은 HDAC3 [7] Promyelocytic 백혈병 단백질 과 상호작용 하는 것으로 나타났다.[8]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000185386 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000053137 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P (Aug 1997). "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases" . EMBO J . 16 (12): 3563–71. doi :10.1093/emboj/16.12.3563 . PMC 1169981 PMID 9218798 . ^ a b "Entrez Gene: MAPK11 mitogen-activated protein kinase 11" .^ Mahlknecht U, Will J, Varin A, Hoelzer D, Herbein G (Sep 2004). "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression" . J. Immunol . 173 (6): 3979–90. doi :10.4049/jimmunol.173.6.3979 PMID 15356147 . ^ Shin J, Park B, Cho S, Lee S, Kim Y, Lee SO, Cho K, Lee S, Jin BS, Ahn JH, Choi EJ, Ahn K (Sep 2004). "Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase" . J. Biol. Chem . 279 (39): 40994–1003. doi :10.1074/jbc.M407369200 PMID 15273249 .
외부 링크 추가 읽기 Jiang Y, Chen C, Li Z, Guo W, Gegner JA, Lin S, Han J (1996). "Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)" . J. Biol. Chem . 271 (30): 17920–6. doi :10.1074/jbc.271.30.17920 PMID 8663524 . Kumar S, McDonnell PC, Gum RJ, Hand AT, Lee JC, Young PR (1997). "Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles". Biochem. Biophys. Res. Commun . 235 (3): 533–8. doi :10.1006/bbrc.1997.6849 . PMID 9207191 . Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS (1997). "p38-2, a novel mitogen-activated protein kinase with distinct properties" . J. Biol. Chem . 272 (31): 19509–17. doi :10.1074/jbc.272.31.19509 PMID 9235954 . Enslen H, Raingeaud J, Davis RJ (1998). "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6" . J. Biol. Chem . 273 (3): 1741–8. doi :10.1074/jbc.273.3.1741 PMID 9430721 . New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J (1998). "PRAK, a novel protein kinase regulated by the p38 MAP kinase" . EMBO J . 17 (12): 3372–84. doi :10.1093/emboj/17.12.3372 . PMC 1170675 PMID 9628874 . Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . EMBO J . 17 (15): 4426–41. doi :10.1093/emboj/17.15.4426 . PMC 1170775 PMID 9687510 . Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. doi :10.1038/990031 PMID 10591208 . Lee SH, Park J, Che Y, Han PL, Lee JK (2000). "Constitutive activity and differential localization of p38alpha and p38beta MAPKs in adult mouse brain". J. Neurosci. Res . 60 (5): 623–31. doi :10.1002/(SICI)1097-4547(20000601)60:5<623::AID-JNR7>3.0.CO;2-4 . PMID 10820433 . Tanoue T, Yamamoto T, Maeda R, Nishida E (2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs" . J. Biol. Chem . 276 (28): 26629–39. doi :10.1074/jbc.M101981200 PMID 11359773 . Torcia M, De Chiara G, Nencioni L, Ammendola S, Labardi D, Lucibello M, Rosini P, Marlier LN, Bonini P, Dello Sbarba P, Palamara AT, Zambrano N, Russo T, Garaci E, Cozzolino F (2001). "Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release" (PDF) . J. Biol. Chem . 276 (42): 39027–36. doi :10.1074/jbc.M102970200 PMID 11495898 . Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J (2002). "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha". Science . 295 (5558): 1291–4. doi :10.1126/science.1067289 . PMID 11847341 . Reunanen N, Li SP, Ahonen M, Foschi M, Han J, Kähäri VM (2002). "Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization" . J. Biol. Chem . 277 (35): 32360–8. doi :10.1074/jbc.M204296200 PMID 12060661 . Knebel A, Haydon CE, Morrice N, Cohen P (2002). "Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways" . Biochem. J . 367 (Pt 2): 525–32. doi :10.1042/BJ20020916 . PMC 1222910 PMID 12171600 . Kinet S, Bernard F, Mongellaz C, Perreau M, Goldman FD, Taylor N (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes" . Blood . 100 (7): 2546–53. doi :10.1182/blood-2002-03-0819 PMID 12239168 . Lim S, Zou Y, Friedman E (2002). "The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase" . J. Biol. Chem . 277 (51): 49438–45. doi :10.1074/jbc.M206840200 PMID 12384504 . Naderi J, Hung M, Pandey S (2003). "Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: resistance of quiescent cells to oxidative stress". Apoptosis . 8 (1): 91–100. doi :10.1023/A:1021657220843 . PMID 12510156 . Stringaris AK, Geisenhainer J, Bergmann F, Balshüsemann C, Lee U, Zysk G, Mitchell TJ, Keller BU, Kuhnt U, Gerber J, Spreer A, Bähr M, Michel U, Nau R (2002). "Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase". Neurobiol. Dis . 11 (3): 355–68. doi :10.1006/nbdi.2002.0561 . hdl :11858/00-001M-0000-0012-F282-1 PMID 12586546 .
