리보솜 단백질 S6키나제 알파-4 는 인간에게 RPS6KA4 유전자에 의해 암호화 된 효소 다.[5] [6] [7]
함수 이 유전자는 세린/ 트레오닌 키나아제 의 RSK(리보솜 S6 kinase ) 계열의 구성원을 인코딩한다. 이 키나아제는 2개의 비식별 키나아제 촉매 도메인을 포함하고 있으며, CREB1 과 c-Fos 를 포함한 다양한 기판을 인산염화 한다. 이 유전자의 대체 전사적 스플라이스 변형은 관찰되었지만 완전히 특징지어지지는 않았다.[7]
상호작용 RPS6KA4는 MAPK14 와 상호작용 하는 것으로 나타났다.[5]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000162302 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000118668 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)" . J Biol Chem . 273 (45): 29661–29671. doi :10.1074/jbc.273.45.29661 PMID 9792677 . ^ Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . EMBO J . 17 (15): 4426–4441. doi :10.1093/emboj/17.15.4426 . PMC 1170775 PMID 9687510 . ^ a b "Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4" . 추가 읽기 Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science . 273 (5277): 959–963. Bibcode :1996Sci...273..959X . doi :10.1126/science.273.5277.959 . PMID 8688081 . S2CID 22226803 . Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB" . J. Biol. Chem . 273 (49): 32377–32379. doi :10.1074/jbc.273.49.32377 PMID 9829964 . Tomás-Zuber M, Mary JL, Lesslauer W (2000). "Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor" . J. Biol. Chem . 275 (31): 23549–23558. doi :10.1074/jbc.M002586200 PMID 10806207 . Tomás-Zuber M, Mary JL, Lamour F, et al. (2001). "C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)" . J. Biol. Chem . 276 (8): 5892–5899. doi :10.1074/jbc.M005822200 PMID 11035004 . Gudi T, Casteel DE, Vinson C, et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation" . Oncogene . 19 (54): 6324–6333. doi :10.1038/sj.onc.1204007 PMID 11175347 . Prymakowska-Bosak M, Misteli T, Herrera JE, et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin" . Mol. Cell. Biol . 21 (15): 5169–5178. doi :10.1128/MCB.21.15.5169-5178.2001 . PMC 87241 PMID 11438671 . Wiggin GR, Soloaga A, Foster JM, et al. (2002). "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts" . Mol. Cell. Biol . 22 (8): 2871–2881. doi :10.1128/MCB.22.8.2871-2881.2002 . PMC 133730 PMID 11909979 . Soloaga A, Thomson S, Wiggin GR, et al. (2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14" . EMBO J . 22 (11): 2788–2797. doi :10.1093/emboj/cdg273 . PMC 156769 PMID 12773393 . Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry" . Mol. Cell. Proteomics . 6 (3): 537–547. doi :10.1074/mcp.T600062-MCP200 PMID 17192257 . Gesser B, Johansen C, Rasmussen MK, et al. (2007). "Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect" . J. Invest. Dermatol . 127 (9): 2129–2137. doi :10.1038/sj.jid.5700859 PMID 17495961 .
