미오신V형 단백질인 미오신Vb는 인간의 MYO5B 유전자에 의해 암호화된다.[5][6][7][8]
마이오신-Vb가 덴드리트리틱스파에서 엔도솜을 재활용하는 것을 포함한 AMPA 수용체를 액틴 의존적으로 밀거래함으로써 기억을 만들어내는[9] 것과 관련이 있다는 최근의 증거가 제시되고 있다.[10]
MYO5B의 돌연변이는 비피질 및 기저질 단백질의 거래 결함으로 인한 미생물 포함 질환을 유발한다.[8]
MYO5B는 또한 조울증과 관련이 있다.[11]
상호작용
MYO5B는 RAB11FIP2와 상호작용하는 것으로 나타났다.[12]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000167306 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000025885 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Sep 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
- ^ Swiatecka-Urban A, Talebian L, Kanno E, Moreau-Marquis S, Coutermarsh B, Hansen K, Karlson KH, Barnaby R, Cheney RE, Langford GM, Fukuda M, Stanton BA (Aug 2007). "Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells". The Journal of Biological Chemistry. 282 (32): 23725–36. doi:10.1074/jbc.M608531200. PMID 17462998.
- ^ "Entrez Gene: MYO5B myosin VB".
- ^ a b Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P, Ponstingl H, Partsch J, Röllinghoff B, Köhler H, Berger T, Lenhartz H, Schlenck B, Houwen RJ, Taylor CJ, Zoller H, Lechner S, Goulet O, Utermann G, Ruemmele FM, Huber LA, Janecke AR (Oct 2008). "MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity". Nature Genetics. 40 (10): 1163–5. doi:10.1038/ng.225. PMID 18724368. S2CID 205345488.
- ^ "DukeHealth.org: Scientists Identify Machinery that Helps Make Memories". Retrieved 2014-03-25.
- ^ Wang Z, Edwards JG, Riley N, Provance DW, Karcher R, Li XD, Davison IG, Ikebe M, Mercer JA, Kauer JA, Ehlers MD (Oct 2008). "Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity". Cell. 135 (3): 535–48. doi:10.1016/j.cell.2008.09.057. PMC 2585749. PMID 18984164.
- ^ Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM (Jun 2008). "Whole-genome association study of bipolar disorder". Molecular Psychiatry. 13 (6): 558–69. doi:10.1038/sj.mp.4002151. PMC 3777816. PMID 18317468.
- ^ Hales CM, Vaerman JP, Goldenring JR (Dec 2002). "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling". The Journal of Biological Chemistry. 277 (52): 50415–21. doi:10.1074/jbc.M209270200. PMID 12393859.
추가 읽기
- Huang WM, Reed-Fourquet L, Wu E, Wu JY (Nov 1990). "Molecular cloning and amino acid sequence of brain L-glutamate decarboxylase". Proceedings of the National Academy of Sciences of the United States of America. 87 (21): 8491–5. Bibcode:1990PNAS...87.8491H. doi:10.1073/pnas.87.21.8491. PMC 54982. PMID 2236059.
- Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (Jul 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
- Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Oct 1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
- Lapierre LA, Kumar R, Hales CM, Navarre J, Bhartur SG, Burnette JO, Provance DW, Mercer JA, Bähler M, Goldenring JR (Jun 2001). "Myosin vb is associated with plasma membrane recycling systems". Molecular Biology of the Cell. 12 (6): 1843–57. doi:10.1091/mbc.12.6.1843. PMC 37346. PMID 11408590.
- Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR (Oct 2001). "Identification and characterization of a family of Rab11-interacting proteins". The Journal of Biological Chemistry. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
- Hales CM, Vaerman JP, Goldenring JR (Dec 2002). "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling". The Journal of Biological Chemistry. 277 (52): 50415–21. doi:10.1074/jbc.M209270200. PMID 12393859.
- Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
- Fan GH, Lapierre LA, Goldenring JR, Sai J, Richmond A (May 2004). "Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis". Molecular Biology of the Cell. 15 (5): 2456–69. doi:10.1091/mbc.E03-09-0706. PMC 404037. PMID 15004234.
- Wakabayashi Y, Dutt P, Lippincott-Schwartz J, Arias IM (Oct 2005). "Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15087–92. Bibcode:2005PNAS..10215087W. doi:10.1073/pnas.0503702102. PMC 1257697. PMID 16214890.
외부 링크
