SDZ SER-082

SDZ SER-082
식별자
	IUPAC 이름 (+--cis 4,5,7a, 8,9,10,11,11a-옥타하이드로-7H-10-메틸린돌로[1,7-BC][2,6]-나프시리딘;
CAS 번호	141474-54-6 ;
펍켐 CID	9859407;
IUPHAR/BPS	195;
켐스파이더	8035107 ;
유니	M7FHF24Q22;
화학 및 물리적 데이터
공식	C15H20N2
어금질량	228.339 g·2011−1
3D 모델(JSmol)	인터랙티브 이미지;
	스마일즈 CN1CC[C@H]2CN3CC4=C3C(=CC=C4)[C@H]2C1;
	인치 InChi=1S/C15H20N2/c1-16-7-5-12-9-17-8-6-11-2-4-13(15(11)14(12)10-16/4,12,14H,5-10H2,1H3/t12,14/m1s1 ; 키:YASBOGFWAMXINH-TZMCWYMSA-N ;
	(이게 뭐야?) (iii)

SDZ SER-082는 5-HT_2B 수용체와 5-HT_2C 세로토닌 수용체의 혼합 길항제 역할을 하는 약물로, 다른 세로토닌 수용체 하위 유형보다 선택성이 우수하고 5-HT_2B 대비 5-HT를_2C 약간 선호한다.^[1] 그것은 다른 5-HT₂ 하위 유형의 행동 효과와 ^[2]^[3]^[4]그것들이 코카인과 같은 다른 약물의 효과에 어떻게 영향을 미치는가에 대한 동물 연구에 사용되어 왔다.^[5]^[6]^[7]

참조

^ Nozulak J, Kalkman HO, Floerscheim P, Hoyer D, Schoeffter P, Buerki HR. (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity. 의학저널. 1995년 1월;38(1):28-33. 도이:10.1021/jm00001a007
^ Mora PO, Netto CF, Graeff FG (December 1997). "Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze". Pharmacology Biochemistry and Behavior. 58 (4): 1051–7. doi:10.1016/S0091-3057(97)00057-9. PMID 9408213.
^ Dave KD, Harvey JA, Aloyo VJ (May 2002). "A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation". Pharmacology Biochemistry and Behavior. 72 (1–2): 371–8. doi:10.1016/S0091-3057(01)00767-5. PMID 11900808.
^ Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (October 2008). "Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat". Pharmacology Biochemistry and Behavior. 90 (4): 632–9. doi:10.1016/j.pbb.2008.05.006. PMID 18572227.
^ Filip M, Bubar MJ, Cunningham KA (September 2004). "Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses". The Journal of Pharmacology and Experimental Therapeutics. 310 (3): 1246–54. doi:10.1124/jpet.104.068841. PMID 15131246.
^ Filip M (2005). "Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats". Pharmacological Reports. 57 (1): 35–46. PMID 15849375.
^ Filip M, Bubar MJ, Cunningham KA (January 2006). "Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats". Psychopharmacology. 183 (4): 482–9. doi:10.1007/s00213-005-0197-y. PMID 16261316.

신경계통에 관한 이 약물 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.

[1] Nozulak J, Kalkman HO, Floerscheim P, Hoyer D, Schoeffter P, Buerki HR. (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity. 의학저널. 1995년 1월;38(1):28-33. 도이:10.1021/jm00001a007

[pmid9408213-2] Mora PO, Netto CF, Graeff FG (December 1997). "Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze". Pharmacology Biochemistry and Behavior. 58 (4): 1051–7. doi:10.1016/S0091-3057(97)00057-9. PMID 9408213.

[pmid11900808-3] Dave KD, Harvey JA, Aloyo VJ (May 2002). "A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation". Pharmacology Biochemistry and Behavior. 72 (1–2): 371–8. doi:10.1016/S0091-3057(01)00767-5. PMID 11900808.

[pmid18572227-4] Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (October 2008). "Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat". Pharmacology Biochemistry and Behavior. 90 (4): 632–9. doi:10.1016/j.pbb.2008.05.006. PMID 18572227.

[pmid15131246-5] Filip M, Bubar MJ, Cunningham KA (September 2004). "Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses". The Journal of Pharmacology and Experimental Therapeutics. 310 (3): 1246–54. doi:10.1124/jpet.104.068841. PMID 15131246.

[pmid15849375-6] Filip M (2005). "Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats". Pharmacological Reports. 57 (1): 35–46. PMID 15849375.

[pmid16261316-7] Filip M, Bubar MJ, Cunningham KA (January 2006). "Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats". Psychopharmacology. 183 (4): 482–9. doi:10.1007/s00213-005-0197-y. PMID 16261316.

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SDZ SER-082

네임스페이스

더

참조

식별자

IUPAC 이름 (+--cis 4,5,7a, 8,9,10,11,11a-옥타하이드로-7H-10-메틸린돌로[1,7-BC][2,6]-나프시리딘
CAS 번호	141474-54-6^Y
펍켐 CID	9859407
IUPHAR/BPS	195
켐스파이더	8035107^N
유니	M7FHF24Q22
화학 및 물리적 데이터
공식	C₁₅H₂₀N₂
어금질량	228.339 g·2011⁻¹
3D 모델(JSmol)	인터랙티브 이미지
스마일즈 CN1CC[C@H]2CN3CC4=C3C(=CC=C4)[C@H]2C1
인치 InChi=1S/C15H20N2/c1-16-7-5-12-9-17-8-6-11-2-4-13(15(11)14(12)10-16/4,12,14H,5-10H2,1H3/t12,14/m1s1^N 키:YASBOGFWAMXINH-TZMCWYMSA-N^N
^NY (이게 뭐야?) (iii)