호모사피엔스 종의 단백질 코딩 유전자
알파 택실린은 인터루킨-14 (IL-14) 또는 고분자량 B세포 성장인자 (HMW-BCGF)로도 알려져 있으며 인간에서 TXLNA 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
인터루킨-14는 정상 B세포와 암 B세포의 성장과 증식 을 모두 조절하는 사이토카인 이다.[8] 이 분자는 또한 최근에 택실린으로 지정되었다.[9] IL-14는 B세포 증식을 유도하고 항체 분비를 억제하며 선택된 B세포 부분군을 확대한다. 이 인터루킨 은 주로 T세포 와 특정 악성 B세포에 의해 생성된다.
유전자 뮤린 모델에서는 IL-14α와 IL-14β라고 불리는 IL14 유전자 의 반대편 가닥으로부터 두 개의 뚜렷한 대본 이 생성된다.[10] Il14 locus는 인간의 1번 염색체의 LCK 유전자 근처에 있다.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000084652 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000053841 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun . 319 (3): 936–43. doi :10.1016/j.bbrc.2004.05.073 . PMID 15184072 . ^ Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun . 311 (4): 797–802. doi :10.1016/j.bbrc.2003.10.069 . PMID 14623251 . ^ "Entrez Gene: TXLNA taxilin alpha" .^ Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (July 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor" . Proc. Natl. Acad. Sci. U.S.A . 90 (13): 6330–4. Bibcode :1993PNAS...90.6330A . doi :10.1073/pnas.90.13.6330 PMC 46922 PMID 8327514 . ^ Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (January 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells" . Genes Cells . 8 (1): 17–28. doi :10.1046/j.1365-2443.2003.00612.x PMID 12558796 . ^ Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (October 2006). "Development of autoimmunity in IL-14alpha-transgenic mice" . J. Immunol . 177 (8): 5676–86. doi :10.4049/jimmunol.177.8.5676 PMID 17015757 . S2CID 86324456 .
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