S-15535

S-15535
S-15535
S-15535 structure.png
임상자료
ATC 코드
  • 없는
식별자
  • 1-(2,3-디하이드로-1,4-벤조다이오신-8-yl)-4-(2,3-디하이드로-1H-inden-2-yl)피페라진
CAS 번호
펍켐 CID
IUPHAR/BPS
켐스파이더
켐벨
CompTox 대시보드 (EPA)
ECHA InfoCard100.150.279 Edit this at Wikidata
화학 및 물리적 데이터
공식C21H24N2O2
어금질량336.435 g·190−1
3D 모델(JSmol)
  • C1CN(CCN1C2CC3=CC=CC=C3C2)C4=C5C(=CC=C4)OCO5
  • InChi=1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-24-20-21(19)25-13-12-24-20/H1-20,18H,8-15H ☒N)
  • 키:QJPPEMXOWNICQ-UHFFFAOYSA-N ☒N
☒NcheckY (이게 뭐야?) (iii)

S-15535는 페닐피페라진 약물로, 전시냅스 및 후시냅스1A 5-HT 수용체에서 각각 작용제 및 길항제(약한 부분작용제) 역할을 하는 강력하고 선택성이 높은 5-HT1A 수용체 리간드(ligand)이다.[1][2][3][4] 그것은 불안정한 성질을 가지고 있다.[4][5]

참고 항목

참조

  1. ^ Millan MJ, Rivet JM, Canton H, Lejeune F, Gobert A, Widdowson P, Bervoets K, Brocco M, Peglion JL (1993). "S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist (weak partial agonist) at presynaptic and postsynaptic sites respectively". Eur J Pharmacol. 230 (1): 99–102. doi:10.1016/0014-2999(93)90416-F. PMID 8381359.
  2. ^ Millan MJ, Canton H, Gobert A, Lejeune F, Rivet JM, Bervoets K, Brocco M, Widdowson P, Mennini T, Audinot V, et al. (1994). "Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists". J Pharmacol Exp Ther. 268 (1): 337–352. PMID 8301575.
  3. ^ Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A (1997). "S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity". J Pharmacol Exp Ther. 282 (1): 132–147. PMID 9223549.
  4. ^ a b Lejeune F, Millan MJ (1998). "Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535". Synapse. 30 (2): 172–180. doi:10.1002/(SICI)1098-2396(199810)30:2<172::AID-SYN7>3.0.CO;2-9. PMID 9723787.
  5. ^ Dekeyne A, Brocco M, Adhumeau A, Gobert A, Millan MJ (2000). "The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents". Psychopharmacology. 152 (1): 55–66. doi:10.1007/s002130000449. PMID 11041316. S2CID 2511149.