푸코실전달효소3

FUT3
식별자
에일리어스	FUT3, CD174, FT3B, FucT-III, LE, Les, 푸코실전달효소3, 푸코실전달효소3(루이스 혈액형)
외부 ID	HomoloGene: 128031 GenCard: FUT3
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	5,851,474 bp
RNA발현패턴
	상단 표시 위치:
	구강; ; 직장; ; 소침샘; ; 십이지장; ; 양수; ; 설체; ; 담낭; ; 췌관 세포; ; 혀 윗면; ; 기관;
	없음
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	트랜스페라아제 활성; α-(1->3)-푸코실전달효소활성; 푸코실전달효소활성; 글리코실전달효소활성; 3-갈락토실-N-아세틸글루코사미드 4-α-L-푸코실전달효소활성;
셀룰러 컴포넌트	막의 적분 성분; 골지 시스테나막; 골지 장치; 세포외 엑소좀; 막; 골지막;
생물학적 과정	세포인식; 올리고당생합성법; 단백질 글리코실화; 고분자 글리코실화; 푸코실화; 세라마이드 대사 과정;
	출처:아미고 / QuickGO
맞춤법
	2525
	없음
	ENSG00000171124
	없음
	P21217
	없음
	NM_000149; NM_001097639; NM_001097640; NM_001097641; NM_001374740
	없음
NP_000140; NP_001091108; NP_001091109; NP_001091110; NP_001361669;
	NP_001369673; NP_001369674; NP_001369675; NP_001369676; NP_001369677; NP_001369678; NP_001369679
	없음
	위키데이터
인간 보기/편집

갈락토시드3(4)-L-푸코실전달효소(L-fucosyl transferase)는 FUT3 ^[3]^[4]^[5]유전자에 의해 인체 내에서 암호화되는 효소이다.

기능.

루이스 히스토 혈액형 시스템은 외분비 상피세포에 의해 합성되어 체액 내에서 순환하는 푸코실화 글리코스핑고지질 세트를 포함한다.글리코스핑고지질들은 발생, 조직 분화, 종양 전이, 염증, 세균 접착에서 기능한다.그들은 두 번째로 적혈구에 흡수되어 루이스 표현형을 만들어낸다.이 유전자는 루이스 항원 생합성 마지막 단계에서 전구체 다당류에 푸코스를 첨가하는 것을 촉매하는 푸코실전달효소 계열의 구성원이다.α(1,3)-푸코실전달효소 및 α(1,4)-푸코실전달효소 활성으로 효소를 코드한다.이 유전자의 돌연변이는 루이스 항원 음성 표현형의 대부분을 차지한다.이 ^[5]유전자에 대해 동일한 단백질을 코드하는 여러 대체 접합 변형이 발견되었다.

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차별화 클러스터

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000171124 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB (Aug 1990). "A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase". Genes & Development. 4 (8): 1288–303. doi:10.1101/gad.4.8.1288. PMID 1977660.
^ Weston BW, Nair RP, Larsen RD, Lowe JB (Feb 1992). "Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities". The Journal of Biological Chemistry. 267 (6): 4152–60. doi:10.1016/S0021-9258(19)50641-X. PMID 1740457.
^ ^a ^b "Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)".

추가 정보

Cameron HS, Szczepaniak D, Weston BW (Aug 1995). "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms". The Journal of Biological Chemistry. 270 (34): 20112–22. doi:10.1074/jbc.270.34.20112. PMID 7650030.
Reguigne-Arnould I, Couillin P, Mollicone R, Fauré S, Fletcher A, Kelly RJ, Lowe JB, Oriol R (1995). "Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19". Cytogenetics and Cell Genetics. 71 (2): 158–62. doi:10.1159/000134098. PMID 7656588.
Nishihara S, Nakazato M, Kudo T, Kimura H, Ando T, Narimatsu H (Jan 1993). "Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19". Biochemical and Biophysical Research Communications. 190 (1): 42–6. doi:10.1006/bbrc.1993.1008. PMID 7916594.
Nishihara S, Narimatsu H, Iwasaki H, Yazawa S, Akamatsu S, Ando T, Seno T, Narimatsu I (Nov 1994). "Molecular genetic analysis of the human Lewis histo-blood group system". The Journal of Biological Chemistry. 269 (46): 29271–8. doi:10.1016/S0021-9258(19)62041-7. PMID 7961897.
Mollicone R, Reguigne I, Kelly RJ, Fletcher A, Watt J, Chatfield S, Aziz A, Cameron HS, Weston BW, Lowe JB (Aug 1994). "Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees". The Journal of Biological Chemistry. 269 (33): 20987–94. doi:10.1016/S0021-9258(17)31919-1. PMID 8063716.
Koda Y, Kimura H, Mekada E (Nov 1993). "Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals". Blood. 82 (9): 2915–9. doi:10.1182/blood.V82.9.2915.2915. PMID 8219240.
Elmgren A, Rydberg L, Larson G (Oct 1993). "Genotypic heterogeneity among Lewis negative individuals". Biochemical and Biophysical Research Communications. 196 (2): 515–20. doi:10.1006/bbrc.1993.2280. PMID 8240322.
Nishihara S, Yazawa S, Iwasaki H, Nakazato M, Kudo T, Ando T, Narimatsu H (Oct 1993). "Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals". Biochemical and Biophysical Research Communications. 196 (2): 624–31. doi:10.1006/bbrc.1993.2295. PMID 8240337.
Elmgren A, Börjeson C, Svensson L, Rydberg L, Larson G (1996). "DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group system". Vox Sanguinis. 70 (2): 97–103. doi:10.1111/j.1423-0410.1996.tb01300.x. PMID 8801770. S2CID 42984604.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Orntoft TF, Vestergaard EM, Holmes E, Jakobsen JS, Grunnet N, Mortensen M, Johnson P, Bross P, Gregersen N, Skorstengaard K, Jensen UB, Bolund L, Wolf H (Dec 1996). "Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels". The Journal of Biological Chemistry. 271 (50): 32260–8. doi:10.1074/jbc.271.50.32260. PMID 8943285.
Elmgren A, Mollicone R, Costache M, Börjeson C, Oriol R, Harrington J, Larson G (Aug 1997). "Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII". The Journal of Biological Chemistry. 272 (35): 21994–8. doi:10.1074/jbc.272.35.21994. PMID 9268337.
Pang H, Liu Y, Koda Y, Soejima M, Jia J, Schlaphoff T, Du Toit ED, Kimura H (Jun 1998). "Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa". Human Genetics. 102 (6): 675–80. doi:10.1007/s004390050760. PMID 9703429. S2CID 12651016.
Nishihara S, Hiraga T, Ikehara Y, Iwasaki H, Kudo T, Yazawa S, Morozumi K, Suda Y, Narimatsu H (Apr 1999). "Molecular behavior of mutant Lewis enzymes in vivo". Glycobiology. 9 (4): 373–82. doi:10.1093/glycob/9.4.373. PMID 10089211.
Yazawa S, Tanaka S, Nishimura T, Miyanaga K, Kochibe N (1999). "Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia". Experimental and Clinical Immunogenetics. 16 (3): 125–30. doi:10.1159/000019104. PMID 10394050. S2CID 85281056.
Holmes EH, Yen TY, Thomas S, Joshi R, Nguyen A, Long T, Gallet F, Maftah A, Julien R, Macher BA (Aug 2000). "Human alpha 1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sites". The Journal of Biological Chemistry. 275 (32): 24237–45. doi:10.1074/jbc.M000888200. PMID 10816554.
Grahn A, Elmgren A, Aberg L, Svensson L, Jansson PA, Lönnroth P, Larson G (Oct 2001). "Determination of Lewis FUT3 gene mutations by PCR using sequence-specific primers enables efficient genotyping of clinical samples". Human Mutation. 18 (4): 358–9. doi:10.1002/humu.1204. PMID 11668626. S2CID 33547478.
Roos C, Kolmer M, Mattila P, Renkonen R (Feb 2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". The Journal of Biological Chemistry. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.

외부 링크

CD174+미국국립의학도서관 의학분야 제목(MeSH)의 항원균

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000171124 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1977660-3] Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB (Aug 1990). "A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase". Genes & Development. 4 (8): 1288–303. doi:10.1101/gad.4.8.1288. PMID 1977660.

[pmid1740457-4] Weston BW, Nair RP, Larsen RD, Lowe JB (Feb 1992). "Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities". The Journal of Biological Chemistry. 267 (6): 4152–60. doi:10.1016/S0021-9258(19)50641-X. PMID 1740457.

[entrez-5] "Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)".

[1]

[2]

[3]

[4]

[5]

v t 단백질: 분화의 클러스터(분화의 인간 클러스터 목록 참조)
1–50	CD1 교류 1A 1B 1차원 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a) d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDW198 CDW199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDW210 a b CD212 CD213a 1 2 CD217 CD218 (a) b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDW293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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푸코실전달효소3

네임스페이스

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레퍼런스

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푸코실전달효소3

기능.

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