KER2DL1
KIR2DL1
킬러 세포 면역글로불린 유사 수용체 2DL1은 인간 내 KIR2DL1 유전자에 의해 암호화된 단백질이다.[3][4][5]
함수
킬러 세포 면역글로불린 유사 수용체(KIRs)는 자연 킬러 세포와 T 세포의 서브셋에 의해 발현되는 트랜섬브레인 당단백질이다.KIR 유전자는 다형성 및 고동맥성으로 1Mb 백혈구 수용체 복합체(LRC) 내 염색체 19q13.4의 성단에서 발견된다.여러 "프레임워크" 유전자가 모든 하플라타입(KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2)에서 발견되지만 KIR 유전자 군집의 유전자 함량은 하플라타입에 따라 다르다.KIR 단백질은 세포외 면역글로불린 영역 수(2D 또는 3D)와 세포질 영역이 긴지 짧은지(S)로 분류된다.면역 티로신 기반 억제 모티브(ITIM)를 통해 리간드 결합 시 긴 세포질 영역 변환 억제 신호를 가진 KIR 단백질은 ITIM 모티브가 부족한 반면, 짧은 세포질 영역을 가진 KIR 단백질은 대신 TYRO 단백질 티로신 키나제 결합 단백질과 결합하여 변환 활성 신호를 만든다.몇몇 KIR 단백질의 리간드는 HLA 등급 I 분자의 하위 집합이므로, KIR 단백질은 면역 반응의 조절에 중요한 역할을 한다고 생각된다.[5]
상호작용
KIR2DL1은 HLA-C와 상호작용하는 것으로 나타났다.[6][7][8][9]
참고 항목
참조
- ^ a b c ENSG00000275196, ENSG00000278805, ENSG00000125498, ENSG00000284401, ENSG00000278755, ENSG00000278495, ENSG00000278738, ENSG00000278248, ENSG00000278503, ENSG00000284530, ENSG00000276820, ENSG00000275080, ENSG00000275276, ENSG00000273794, ENSG00000276625, ENSG00000277616, ENSG00000284100, ENSG00000284514, ENSG00000283723, ENSG00000274926, ENSG00000278207, ENSG00000274782, ENSG00000284347, ENSG00000273510, ENSG00000274692, ENSG00000277833, ENSG00000276310, ENSG00000284551, ENSG00000275750, ENSG00000275522, ENSG00000277356, ENSG00000284145, ENSG00000276387 GRCh38: Ensembl release 89: ENSG00000278821, ENSG00000275196, ENSG00000278805, ENSG00000125498, ENSG00000284401, ENSG00000278755, ENSG00000278495, ENSG00000278738, ENSG00000278248, ENSG00000278503, ENSG00000284530, ENSG00000276820, ENSG00000275080, ENSG00000275276, ENSG00000273794, ENSG00000276625, ENSG00000277616, ENSG00000284100, ENSG00000284514, ENSG00000283723, ENSG00000274926, ENSG00000278207, ENSG00000274782, ENSG00000284347, ENSG00000273510, ENSG00000274692, ENSG00000277833, ENSG00000276310, ENSG00000284551, ENSG00000275750, ENSG00000275522, ENSG00000277356, ENSG00000284145, ENSG00000276387 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (June 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity. 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980.
- ^ Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science. 268 (5209): 405–8. Bibcode:1995Sci...268..405C. doi:10.1126/science.7716543. PMID 7716543.
- ^ a b "Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1".
- ^ Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL (December 2002). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16180–5. Bibcode:2002PNAS...9916180B. doi:10.1073/pnas.212643199. PMC 138585. PMID 12454284.
- ^ Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL (December 2000). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. 61 (12): 1202–18. doi:10.1016/S0198-8859(00)00184-1. PMID 11163076.
- ^ Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (September 1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337–44. doi:10.1016/S1074-7613(00)80616-0. PMID 9768753.
- ^ Fan QR, Long EO, Wiley DC (May 2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. 2 (5): 452–60. doi:10.1038/87766. PMID 11323700. S2CID 24707532.
추가 읽기
- Fan QR, Mosyak L, Winter CC, Wagtmann N, Long EO, Wiley DC (1997). "Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors". Nature. 389 (6646): 96–100. Bibcode:1997Natur.389...96F. doi:10.1038/38028. PMID 9288975. S2CID 4365964.
- Kim J, Chwae YJ, Kim MY, Choi IH, Park JH, Kim SJ (1997). "Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors". J. Immunol. 159 (8): 3875–82. PMID 9378975.
- Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P (1998). "Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors". Immunity. 7 (6): 739–51. doi:10.1016/S1074-7613(00)80393-3. PMID 9430220.
- Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P (1998). "Human diversity in killer cell inhibitory receptor genes". Immunity. 7 (6): 753–63. doi:10.1016/S1074-7613(00)80394-5. PMID 9430221.
- Rajagopalan S, Long EO (1998). "Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells". J. Immunol. 161 (3): 1299–305. PMID 9686591.
- Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337–44. doi:10.1016/S1074-7613(00)80616-0. PMID 9768753.
- Shilling HG, Lienert-Weidenbach K, Valiante NM, Uhrberg M, Parham P (1998). "Evidence for recombination as a mechanism for KIR diversification". Immunogenetics. 48 (6): 413–6. doi:10.1007/s002510050453. PMID 9799338. S2CID 11887627.
- Chwae YJ, Cho SE, Kim SJ, Kim J (1999). "Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual". Immunol. Lett. 68 (2–3): 267–74. doi:10.1016/S0165-2478(99)00062-0. PMID 10424431.
- Fan QR, Wiley DC (1999). "Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor". J. Exp. Med. 190 (1): 113–23. doi:10.1084/jem.190.1.113. PMC 2195553. PMID 10429675.
- Richardson J, Reyburn HT, Luque I, Valés-Gómez M, Strominger JL (2000). "Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site". Eur. J. Immunol. 30 (5): 1480–5. doi:10.1002/(SICI)1521-4141(200005)30:5<1480::AID-IMMU1480>3.0.CO;2-7. PMID 10820396.
- Fan QR, Long EO, Wiley DC (2000). "A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer". Eur. J. Immunol. 30 (9): 2692–7. doi:10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0. PMID 11009104.
- Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL (2001). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. 61 (12): 1202–18. doi:10.1016/S0198-8859(00)00184-1. PMID 11163076.
- Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P (2001). "Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors". Tissue Antigens. 57 (1): 22–31. doi:10.1034/j.1399-0039.2001.057001022.x. PMID 11169255.
- Fan QR, Long EO, Wiley DC (2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. 2 (5): 452–60. doi:10.1038/87766. PMID 11323700. S2CID 24707532.
- Guerra N, Michel F, Gati A, Gaudin C, Mishal Z, Escudier B, Acuto O, Chouaib S, Caignard A (2002). "Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction". Blood. 100 (8): 2874–81. doi:10.1182/blood-2002-02-0643. PMID 12351398.
- Spaggiari GM, Contini P, Dondero A, Carosio R, Puppo F, Indiveri F, Zocchi MR, Poggi A (2003). "Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction". Blood. 100 (12): 4098–107. doi:10.1182/blood-2002-04-1284. PMID 12393468.
- Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL (2003). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16180–5. doi:10.1073/pnas.212643199. PMC 138585. PMID 12454284.
PDB 갤러리 | |
|---|---|
|
이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.
