호모 사피엔스에서 발견된 포유류 단백질
CD84 (Cluster of Differentation 84)는 CD84 유전자 에 의해 인코딩된 인간 단백질 이다.[5]
함수 CD84와 같은 Ig 슈퍼 패밀리의 CD2(MIM 186990 참조) 하위 그룹의 멤버들은 보존된 이황화 결합의 유사한 패턴을 가지고 있으며 T 림프구와 부속 세포 사이의 접착 상호작용에서 기능한다.[5]
상호작용 CD84는 SH2D1A 와 상호작용 하는 것으로 나타났다.[6] [7] [8] [9]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000066294 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000038147 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: CD84 CD84 molecule" .^ Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation" . Journal of Immunology . 171 (5): 2485–95. doi :10.4049/jimmunol.171.5.2485 PMID 12928397 . ^ Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood . 97 (12): 3867–74. doi :10.1182/blood.V97.12.3867 . PMID 11389028 . ^ Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2" . European Journal of Immunology . 32 (6): 1640–9. doi :10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S PMID 12115647 . ^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF) . The Journal of Biological Chemistry . 276 (39): 36809–16. doi :10.1074/jbc.M101305200 PMID 11477068 . S2CID 39889619 .
추가 읽기 Andreesen R, Bross KJ, Osterholz J, Emmrich F (May 1986). "Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens" . Blood . 67 (5): 1257–64. doi :10.1182/blood.V67.5.1257.1257 PMID 3008886 . Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics . 42 (1): 59–62. doi :10.1007/BF00164988 . PMID 7797269 . S2CID 28529549 . de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P (Sep 1997). "CD84 leukocyte antigen is a new member of the Ig superfamily" . Blood . 90 (6): 2398–405. doi :10.1182/blood.V90.6.2398 PMID 9310491 . Krause SW, Rehli M, Heinz S, Ebner R, Andreesen R (Mar 2000). "Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84" . The Biochemical Journal . 346 Pt 3 (3): 729–36. doi :10.1042/0264-6021:3460729 . PMC 1220906 PMID 10698700 . Palou E, Pirotto F, Solé J, Freed JH, Peral B, Vilardell C, Vilella R, Vives J, Gayá A (Feb 2000). "Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains". Tissue Antigens . 55 (2): 118–27. doi :10.1034/j.1399-0039.2000.550203.x . PMID 10746783 . Lucas AD, Chadwick N, Warren BF, Jewell DP, Gordon S, Powrie F, Greaves DR (Mar 2001). "The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo" . The American Journal of Pathology . 158 (3): 855–66. doi :10.1016/S0002-9440(10)64034-5 . PMC 1850344 PMID 11238035 . Shlapatska LM, Mikhalap SV, Berdova AG, Zelensky OM, Yun TJ, Nichols KE, Clark EA, Sidorenko SP (May 2001). "CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A" . Journal of Immunology . 166 (9): 5480–7. doi :10.4049/jimmunol.166.9.5480 PMID 11313386 . Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood . 97 (12): 3867–74. doi :10.1182/blood.V97.12.3867 . PMID 11389028 . Lewis J, Eiben LJ, Nelson DL, Cohen JI, Nichols KE, Ochs HD, Notarangelo LD, Duckett CS (Jul 2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family" . Clinical Immunology . 100 (1): 15–23. doi :10.1006/clim.2001.5035 . PMID 11414741 . Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF) . The Journal of Biological Chemistry . 276 (39): 36809–16. doi :10.1074/jbc.M101305200 PMID 11477068 . S2CID 39889619 . Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P (Oct 2001). "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1" . Journal of Immunology . 167 (7): 3668–76. doi :10.4049/jimmunol.167.7.3668 PMID 11564780 . Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (Nov 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells" . The EMBO Journal . 20 (21): 5840–52. doi :10.1093/emboj/20.21.5840 . PMC 125701 PMID 11689425 . Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2" . European Journal of Immunology . 32 (6): 1640–9. doi :10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S PMID 12115647 . Del Valle JM, Engel P, Martín M (May 2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)" . The Journal of Biological Chemistry . 278 (19): 17430–7. doi :10.1074/jbc.M301569200 PMID 12621057 . Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation" . Journal of Immunology . 171 (5): 2485–95. doi :10.4049/jimmunol.171.5.2485 PMID 12928397 . Zaiss M, Hirtreiter C, Rehli M, Rehm A, Kunz-Schughart LA, Andreesen R, Hennemann B (Sep 2003). "CD84 expression on human hematopoietic progenitor cells". Experimental Hematology . 31 (9): 798–805. doi :10.1016/S0301-472X(03)00187-5 . PMID 12962726 . Romero X, Benítez D, March S, Vilella R, Miralpeix M, Engel P (Aug 2004). "Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)". Tissue Antigens . 64 (2): 132–44. doi :10.1111/j.1399-0039.2004.00247.x . PMID 15245368 . Nanda N, Andre P, Bao M, Clauser K, Deguzman F, Howie D, Conley PB, Terhorst C, Phillips DR (Nov 2005). "Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling" . Blood . 106 (9): 3028–34. doi :10.1182/blood-2005-01-0333 PMID 16037392 . 외부 링크 이 기사는 공공영역 에 있는 미국 국립 의학 도서관 의 텍스트를 통합하고 있다.
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