호모 사피엔스 종의 단백질 코드 유전자
전사인자 Jun-B 는 JUNB [5] [6] 단백질 이다.전사인자 jun-B는 1차 성장인자 반응에 따른 유전자 활성 조절에 관여하는 전사인자 이다. DNA 배열 5'-TGA[CG]TCA-3'에 결합한다.
상호 작용 JUNB는 다음과 같이 상호작용하는 것 으로 나타났습니다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000171223 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000052837 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun" . Cell . 59 (6): 987–997. doi :10.1016/0092-8674(89)90755-1 PMID 2513129 . ^ "Entrez Gene: JUNB jun B proto-oncogene" .^ Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction" . Genes Dev . 16 (12): 1509–17. doi :10.1101/gad.995502 . PMC 186344 PMID 12080089 . ^ Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). 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Genomics . 28 (2): 228–234. doi :10.1006/geno.1995.1135 . PMID 8530030 . Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene . 11 (11): 2255–65. PMID 8570175 . Neyns B, Vermeij J, Bourgain C, Vandamme B, Amfo K, Lissens W, DeSutter P, Hooghe-Peters E, DeGrève J (1996). "Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium". Oncogene . 12 (6): 1247–57. PMID 8649827 . Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE (1996). "Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver" . Proc. Natl. Acad. Sci. U.S.A . 93 (23): 12908–12913. Bibcode :1996PNAS...9312908M . doi :10.1073/pnas.93.23.12908 PMC 24019 PMID 8917518 . Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions" . Mol. Cell. Biol . 17 (6): 3094–102. doi :10.1128/mcb.17.6.3094 . PMC 232162 PMID 9154808 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–156. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors" . J. Biol. Chem . 272 (51): 32163–32168. doi :10.1074/jbc.272.51.32163 PMID 9405416 . Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes" . Oncogene . 17 (24): 3145–3156. doi :10.1038/sj.onc.1202237 PMID 9872330 . Li B, Tournier C, Davis RJ, Flavell RA (1999). "Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation" . EMBO J . 18 (2): 420–432. doi :10.1093/emboj/18.2.420 . PMC 1171136 PMID 9889198 . Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (1999). "Smads bind directly to the Jun family of AP-1 transcription factors" . Proc. Natl. Acad. Sci. U.S.A . 96 (9): 4844–4849. Bibcode :1999PNAS...96.4844L . doi :10.1073/pnas.96.9.4844 PMC 21779 PMID 10220381 . Chen P, Flory E, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR (2000). "Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors" . J. Biol. Chem . 275 (27): 20382–20390. doi :10.1074/jbc.M001149200 PMID 10764760 . Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos" . Oncogene . 19 (14): 1752–1763. doi :10.1038/sj.onc.1203491 PMID 10777209 . Verrecchia F, Pessah M, Atfi A, Mauviel A (2000). "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation" . J. Biol. Chem . 275 (39): 30226–30231. doi :10.1074/jbc.M005310200 PMID 10903323 . Singh K, Camera E, Krug L, Basu A, Pandey RK, Munir S, Wlaschek M, Kochanek S, Schorpp-Kistner M, Picardo M, Angel P, Niemann C, Maity P, Scharffetter-Kochanek K (2018). "JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin" . Nature . 9 (1). doi :10.1038/s41467-018-05726-z PMID 30143626 .
외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY
